“Comparative evaluation of clinicalefficacy of Leukocyte rich Platelet Rich Fibrin (L-PRF) andAdvanced Platelet Rich Fibrin (A-PRF) in the management ofgingival recession defects-A Randomized controlled trialâ€

Gingival recession is described as apical migration of the free gingival margin relative to the cemento enamel junction leading to root exposure. Research in the South Indian population found approximately 40-68% of the subjects had at least one or more gingival recession defects. Gingival recession is often associated with dentinal hypersensitivity, esthetic issues and also root caries. Periodontal plastic procedures aim to achieve complete root coverage while enhancing aesthetics by integrating mucosa and keratinized gingiva with adjacent tissues.

Platelet concentrates aim at extracting all the potential elements present in the collected blood sample and providing supra-physiological concentration at the surgical site to accelerate the healing process and induce regeneration of lost tissues. The second generation platelet concentrates are formed by natural polymerization during centrifugation, resulting in a three-dimensional fibrin architecture with equilateral junctions mimicking the extracellular matrix structure, offering flexibility and elasticity. Low speed centrifugation concept (LSCC) by Choukroun et al 2014 led to the evolution of Advanced platelet rich fibrins (A-PRF, A-PRF+)

Various invitro and invivo studies had shown the positive outcomes with A-PRF in hard and soft tissue regeneration. However, the potential benefit of advanced platelet rich fibrin in management of gingival recession has not yet been established. The aim of this clinical study was to evaluate and compare the clinical efficacy of L-PRF and A-PRF in the treatment of gingival recession defects.