Comparison of Volume Controlled Ventilation and Autoflow-volume Controlled Ventilation in Robot-assisted Laparoscopic Radical Prostatectomy With Steep Trendelenburg Position and Pneumoperitoneum

Not Applicable

Completed

• Conditions: Robot-assisted Laparoscopic Radical Prostatectomy Undergoing General Anesthesia
• Interventions: Other: Autoflow-volume controlled ventilation; Other: Volume controlled ventilation

• Registration Number: NCT02803424
• Lead Sponsor: Yonsei University

Brief Summary

The steep trendelenburg position and pneumoperitoneum during laparoscopic surgery have the potential to cause an adverse effects on respiratory mechanics and gas exchange. Autoflow-volume controlled ventilation may improve lung compliance and reduce airway peak pressure. Therefore, the aim of this study is to evaluate whether Autoflow-volume controlled ventilation improves gas exchange and respiratory mechanics in patients undergoing robot-assisted laparoscopic radical prostatectomy.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-06
• Study First Submitted: 2016-06-09
• Study First Submitted QC: 2016-06-13
• Study First Posted: 2016-06-17
• Status Verified: 2016-12
• Primary Completion: 2016-12
• Study Completion: 2016-12
• Last Update Submitted: 2016-12-25
• Last Update Posted: 2016-12-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

1. Adult male patients scheduled for elective robot-assisted laparoscopic radical prostatectomy undergoing general anesthesia

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Exclusion Criteria

1. chronic obstructive respiratory diseases
2. heart failure
3. body mass index (BMI >30 kg/m2)

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Autoflow-volume controlled ventilation	Autoflow-volume controlled ventilation	During the steep trendelenburg position and pneumoperitoneum, Autoflow-volume controlled ventilation will be applied with 8ml/kg (ideal body weight) and inspiration:expiration ratio (I:E) = 1:2.
Volume controlled ventilation	Volume controlled ventilation	During the steep trendelenburg position and pneumoperitoneum, volume controlled ventilation will be applied with 8ml/kg (ideal body weight) and inspiration:expiration ratio (I:E) = 1:2.

Primary Outcome Measures

Name	Time	Method
arterial oxygen tension (PaO2)	30 minutes after steep trendelenburg position and pneumoperitoneum.	Arterial oxygen tension (PaO2) obtained from arterial blood gas analysis

Secondary Outcome Measures

Name	Time	Method
The peak inspiratory pressure	10 minutes after anesthesia induction, 30 and 60 minutes after steep trendelenburg position and pneumoperitoneum, and 10 minutes after supine position and CO2 desufflation.	The peak inspiratory pressure during mechanical ventilation with endotracheal intubation under general anesthesia

Trial Locations

Locations (1)

Department of Anesthesiology and Pain Medicine Anesthesia and Pain Research Institute Yonsei University; 🇰🇷 Seoul, Korea, Republic of