EFFECT OF SEVOFLURANE VERSUS PROPOFOL ON COGNITIVE FUNCTIONS IN ELDERLY PATIENTS

Not Applicable

• Conditions: Musculoskeletal Diseases; Nervous System Diseases; Surgery; Anaesthesia

• Registration Number: PACTR202110875547798
• Lead Sponsor: Department of Anesthesia and surgical ICU Faculty of medicine Alexandria University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-09-24
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Patients with American Society of Anesthesiologists score of I–II,
of both sex,
age 65 years or older,
have a sufficient level of education to be capable of completing neuropsychological tests,
do not have serious hearing or vision impairment and
are able to read.

Exclusion Criteria

1. Patient’s refusal.
2. ASA III/IV.
3. Mini Mental State Examination (MMSE) score less than 26.
4. Patients with severe hepatic, renal or cardiovascular disease.
5. Pre-existing neurological, dementia or neuropsychological disease
6. Current use of sedatives, antidepressants or corticosteroids
7. History of cerebral surgery or recent stroke.
8. History of alcohol abuse or drug addict.
9. Intraoperative events requiring interventions not included in the
study protocol such as excessive blood loss and severe
hypotension.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary outcome is:<br>Incidence of cognitive dysfunction 120 minutes and 24 hours postoperatively.

Secondary Outcome Measures

Name	Time	Method
Secondary outcome is:<br>• The changes of serum level of S100 beta as a measure of neuronal damage and to correlate the association between S100 beta serum<br>level and incidence of postoperative cognitive dysfunction.<br>• Haemodynamic status.<br>• Use of vasoactive drugs