Intermittent Fasting vs. High-intensity Interval Training on the Lipid Profile of Obese Individuals.

Not Applicable

Completed

• Conditions: Obesity

• Registration Number: NCT06834256
• Lead Sponsor: Cairo University

Brief Summary

we aimed to ascertain the effect of intermittent fasting (IF) vs. high-intensity interval training (HIIT) on the lipid profile and waist circumference (WC) of obese individuals.

Detailed Description

Subjects and Methods: This study included 40 obese individuals of both genders aged 35-50 years with an abnormal lipid profile. The patients were allocated at random to either Group A or B, with both groups receiving medical treatment. Group A followed the IF regime, while Group B performed HIIT on the treadmill three times weekly, with an intervention duration of six weeks for both groups. Body mass index (BMI), WC, levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), alongside the Framingham risk score (FRS) were the evaluated variables.

Study Timeline

• Study Start: 2023-07-01
• Primary Completion: 2024-03-02
• Study Completion: 2024-05-01
• Status Verified: 2025-02
• Study First Submitted: 2025-02-14
• Study First Submitted QC: 2025-02-14
• Last Update Submitted: 2025-02-14
• Study First Posted: 2025-02-19
• Last Update Posted: 2025-02-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Inclusion criteria were as follows: (1) A BMI of 30 -40 kg/m2; (2) abnormal lipid profile, with a TC level > 200 mg/dL, an LDL > 100 mg/dL, a TC level > 150 mg/dL, and an HDL < 40 mg/dL; (3) steady vital signs, including blood pressure, respiration rate, and temperature at a baseline level.

Exclusion Criteria

• The exclusion criteria included patients with the following medical conditions: cancer, unstable angina, uncontrolled cardiac rhythm, decompensated heart failure, persistent systolic blood pressure > 200 mmHg, persistent diastolic blood pressure > 120 mmHg, acute pericarditis or myocarditis, severe restrictive lung disease, chronic chest infection, severe obstructive lung disease, pregnant women, neurological disorders that affect balance and mentality (e.g., epilepsy), orthopedic or neurological problems that interfere with exercises, unstable endocrinal disorders, congenital or acquired lower limb deformity, kidney disease, infectious disease, immune disease, hearing impairment or mental disorder, uncontrolled T2DM.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
lipid profile	lipid profile will be measured at baseline, and it will be measured again after six weeks	A 5 mL fasting venous blood sample was collected following an eight-hour overnight fast, and LDL, HDL, TG, and TC levels were measured.

Secondary Outcome Measures

Name	Time	Method
waist circumference	waist circumference will be measured at baseline, and it will be measured again after six weeks	Utilizing tape measurements to measure WC.A WC \> 40 inches (102 cm) in males and \> 35 inches (88 cm) in women indicated an elevated risk for cardiometabolic disorders
The Framingham risk score (FRS)	The Framingham risk score (FRS) will be measured at baseline, and it will be measured again after six weeks	It was employed to ascertain the cardiovascular disease risk over ten years.

Trial Locations

Locations (1)

Cairo University; 🇪🇬 Cairo, Egypt