Gender and Opioid Consumption

Not Applicable

• Conditions: Postoperative; Parotitis
• Interventions: Drug: postoperative morphine

• Registration Number: NCT03006627
• Lead Sponsor: Mansoura University

Brief Summary

Opioids are widely used for pain relief after major abdominal surgeries\[1\]. Sex differences in the opioid analgesia have been reported and investigated in human subjects and animal models In this study, effects of sex difference on response to opioid analgesics after abdominal surgeries will be assessed regarding; analgesic duration (primary variable), frequency of analgesic requirement, total opioid consumption, Opioid related complications (respiratory depression, Nausea \& vomiting, itching, over-sedation, delayed intestinal motility).

Detailed Description

Not available

Study Timeline

• Status Verified: 2016-12
• Study Start: 2016-12
• Study First Submitted: 2016-12-27
• Study First Submitted QC: 2016-12-29
• Last Update Submitted: 2016-12-29
• Study First Posted: 2016-12-30
• Last Update Posted: 2016-12-30
• Primary Completion: 2017-05
• Study Completion: 2017-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• ASA I and II Cases scheduled for elective intraabdominal surgeries

Exclusion Criteria

• diabetes,
• postmenopausal females,
• laparoscopic surgery,
• regional anesthesia emergency procedures,
• sepsis,
• hepatectomy,
• Renal impairment, and
• hepatic impairment,
• mental and psychiatric disorders.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Male group	postoperative morphine	All male patients scheduled for upper abdominal surgeries
Female group	postoperative morphine	All female patients scheduled for upper abdominal surgeries

Primary Outcome Measures

Name	Time	Method
postoperative morphine consumption	24 hours after surgery