Efficacy of the Extract of Carica Papaya as an Inhibitor of Streptococcus Mutans

Not Applicable

Completed

• Conditions: Dental Plaque; Streptococcus, Other Specified Group
• Interventions: Other: CARICA PAPAYA MOUTHWASH; Other: CHLORHEXIDINE MOUTHWASH

• Registration Number: NCT04485520
• Lead Sponsor: Julieta María Méndez Romero

Brief Summary

Papaya has effects on oral pathogenic microorganisms, it also has anticoagulant quality, amebicidal action, antimicrobial, bacteriostatic and antifungal activity on different bacteria, especially on Streptococcus mutans, this can be exploited in the dental area. The objective of the study was to determine the efficacy of Carica Papaya peel extract (suckling) as an inhibitor of Streptococcus Mutans in students of the dental faculty of the National University of Caaguazú in 2018.

Detailed Description

Specific objectives

* To determine the inhibition of the extract of the peel of Carica Papaya (baby) at 3% on Streptococcus Mutans by age and sex grouping.

* To quantify the inhibition of the extract of the peel of Carica Papaya (baby) at 3% on the growth of Streptococcus Mutans before, at 10 minutes and 8 days of use in the experimental group.

* Quantify the inhibition of 0.12% Chlorhexidine Gluconate on the growth of Streptococcus Mutans before, after 10 minutes and 8 days of use in the control group.

* Compare the count of Colony Forming Units (CFU) between both groups.

Study Timeline

• Study Start: 2017-09-21
• Primary Completion: 2017-10-21
• Study Completion: 2017-10-21
• Study First Submitted: 2020-07-21
• Study First Submitted QC: 2020-07-23
• Study First Posted: 2020-07-24
• Status Verified: 2021-08
• Last Update Submitted: 2021-08-17
• Last Update Posted: 2021-08-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Participants that signed the informed consent

Exclusion Criteria

• allergic to carica papaya
• ongoing medical or dental treatment that could interfere with the results.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Carica Papaya extract	CARICA PAPAYA MOUTHWASH	Carica Papaya at 3%
Chlorhexidine	CHLORHEXIDINE MOUTHWASH	0.12% chlorhexidine mouthwash formulation (commercially available)

Primary Outcome Measures

Name	Time	Method
Number of Colony Forming units (Stage 2)	10 minutes after mouthwash use	After Intervention
Number of Colony Forming units (Stage 3)	8 days after mouthwash use	After Intervention
Number of Colony Forming units (Stage 1)	thorough study completion, an average of 24 hours	Before Intervention

Trial Locations

Locations (1)

Facultad de Odontología Universidad Nacional de Caaguazú; 🇵🇾 Coronel Oviedo, International, Paraguay