Analysis the Positive Status of Tumor Markers Among Physical Examination Population in a Tertiary Grade A Class Hospital
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26,891
- 试验地点
- 1
- 主要终点
- the positive rate of neuron specific enolase（ NSE）
研究概览
简要总结
To analyze the positive rate of tumor markers (TM) among health examination population in a tertiary grade A class hospital, compare the differences between different age and sex groups, and explore the possible influencing factors of TM positive.
详细描述
From January 2019 to December 2019, who underwent physical examination in Peking University Third Hospital were included in the study. The expression levels of carcinoembryonic antigen (CEA),α-fetoprotein (AFP), carbohydrate antigen 19-9 (CA 19-9), carbohydrate antigen-125 (CA-125), carbohydrate antigen 72-4(CA 72-4), carbohydrate antigen 15-3 (CA 15-3), carbohydrate antigen 242(CA 242), squamous cell carcinoma antigen（SCC）, CYFRA21-1, total prostate-specific antigen (TPSA ) , free prostate-specific antigen(FPSA), neuron specific enolase(NSE) were detected by Electro chemistry luminescence method. The positive rates of TM were analyzed by descriptive statistical method Explore. The differences between different age and sex groups and the influencing factors were explored by statistic by Inferential statistical method.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Those who have taken a physical examination and performed at least one TM test
排除标准
- •Basic information is missing and cannot be retrieved
- •The patient was diagnosed with malignant tumor before examination
- •Those who have not done any TM tests
结局指标
主要结局
the positive rate of neuron specific enolase（ NSE）
时间窗: 2019.01.01-2019.12.31
The proportion of abnormal NSE in physical examination population was calculated. The range of normal value ：NSE≤17 ng/mL.
the positive rate of carbohydrate antigen 15-3（CA 15-3）
时间窗: 2019.01.01-2019.12.31
The proportion of abnormal CA 15-3 in physical examination population was calculated. The range of normal value ： CA 15-3≤25 IU/mL.
the positive rate of carbohydrate antigen 242（CA 242）
时间窗: 2019.01.01-2019.12.31
The proportion of abnormal CA 242 in physical examination population was calculated. The range of normal value ：CA 242≤20 U/mL.
the positive rate of squamous cell carcinoma antigen（SCC）
时间窗: 2019.01.01-2019.12.31
The proportion of abnormal SCC in physical examination population was calculated. The range of normal value ：SCC≤1.5 ng/mL.
the positive rate of carbohydrate antigen 19-9（CA 19-9）
时间窗: 2019.01.01-2019.12.31
The proportion of abnormal CA 19-9 in physical examination population was calculated. The range of normal value ： CA 19-9≤39 U/mL.
the positive rate of total prostate-specific antigen（ TPSA）
时间窗: 2019.01.01-2019.12.31
The proportion of abnormal TPSA in physical examination population was calculated. The range of normal value ：TPSA≤4 ng/mL.
the positive rate of α-fetoprotein（AFP）
时间窗: 2019.01.01-2019.12.31
The proportion of abnormal AFP in physical examination population was calculated. The range of normal value ： AFP≤20 ng/mL.
the positive rate of carbohydrate antigen 72-4（CA 72-4）
时间窗: 2019.01.01-2019.12.31
The proportion of abnormal CA 72-4 in physical examination population was calculated. The range of normal value ： CA 72-4≤8.2 U/mL.
the positive rate of carcinoembryonic antigen（CEA）
时间窗: 2019.01.01-2019.12.31
The proportion of abnormal CEA in physical examination population was calculated. The range of normal value ： CEA≤5 ng/mL.
the positive rate of carbohydrate antigen 125（CA 125）
时间窗: 2019.01.01-2019.12.31
The proportion of abnormal CA 125 in physical examination population was calculated. The range of normal value ： CA 125≤35 U/mL.
the positive rate of Cytokeratin 19 fragment 21-1（CYFRA21-1）
时间窗: 2019.01.01-2019.12.31
The proportion of abnormal CYFRA21-1 in physical examination population was calculated. The range of normal value ：CYFRA21-1≤3.3 ng/mL.
the positive rate of free prostate-specific antigen（ FPSA）
时间窗: 2019.01.01-2019.12.31
The proportion of abnormal FPSA in physical examination population was calculated. The range of normal value ：FPSA≤1 ng/mL.
次要结局
- the measured value of Triglyceride (TG)(2019.01.01-2019.12.31)
- the measured value of weight(2019.01.01-2019.12.31)
- age(2019.01.01-2019.12.31)
- the measured value of height(2019.01.01-2019.12.31)
- the measured value of diastolic blood pressure (DBP)(2019.01.01-2019.12.31)
- the measured value of systolic blood pressure (SBP)(2019.01.01-2019.12.31)
- the measured value of fasting bood glucose (FBG)(2019.01.01-2019.12.31)
- the measured value of high density lipoprotein-cholesterol (HDL-C)(2019.01.01-2019.12.31)
- the measured value of total cholesterol (TC)(2019.01.01-2019.12.31)
- the measured value of low density lipoprotein-cholesterol (LDL-C)(2019.01.01-2019.12.31)
- Body Mass Index (BMI)(2019.01.01-2019.12.31)