Synovial fluid concentrations of PGE-2, CTX-I, CTX-II and COMP in the osteoarthritic temporomandibular joint compared to the knee joint

Completed

• Conditions: fibrocartilage breakdown; osteoarthritis; 10023213

• Registration Number: NL-OMON34304
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 90

Inclusion Criteria

Healthy TMJ synovial fluid:
- Patients of the UMCG department of Oral and Maxillofacial Surgery
- Patients undergoing surgery in the TMJ region with symptom free TMJs
- No history of arthropathy
- 20-40 years of age;Synovial fluid obtained from TMJs with OA
- Patient of the UMCG department of Oral and Maxillofacial Surgery
- Patients with OA of the TMJ undergoing arthrocentesis
- 20-40 years of age;Synovial fluid obtained from knee joints with OA
- Patients of the UMCG department of Orthopaedics
- Patients with OA of the knee

Exclusion Criteria

Synovial fluid obtained from TMJs
- History of surgery in the TMJ region
- History or active presence of other rheumatic diseases that could be responsible for secondary osteoarthritis
- Severe articular inflammation as confirmed by physical examination
- Traumatic lesions of the TMJ
- Self reported pregnancy;Synovial fluid obtained from knee joints
- History of intra-articular surgery of the knee
- History or active presence of other rheumatic diseases that could be responsible for secondary osteoarthritis
- Severe articular inflammation as confirmed by physical examination
- Traumatic knee lesions
- Self reported pregnancy

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified