on-invasive measurement of mitochondrial function in vivo in septic patients (a pilot study)
- Conditions
- COVID-19, sepsis
- Registration Number
- NL-OMON23630
- Lead Sponsor
- ot applicable
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 45
Intensive care patients:
In order to be eligible to participate in this study, a subject must meet the following criteria:
•18-90 years of age
•Admission to intensive care ward within 72 hours before inclusion.
Aged and gender matched healthy controls:
•18-90 years of age
•No relevant comorbidities (ASA I/II)
•Matched in age (±5 years) and gender to one of the participants in the COVID 19 group.
A potential subject who meets any of the following criteria will be excluded from participation in this study:
•Mentally disabled
•Porphyria
•Presence of mitochondrial disease
Healthy controls group:
•Presence of COVID-19//sepsis related complains or symptoms
•Presence of COVID-19/sepsis symptoms or complains, or a positive COVID-19 test less than one month ago
•COVID-19 vaccination less than two weeks ago
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mitochondrial oxygen disappearance rate (ODR)
- Secondary Outcome Measures
Name Time Method Cellular oxygen availability in skin (mitoPO2 in mmHg) <br>Mitochondrial function in platelets<br>Mitochondrial DNA in plasma as a marker of mitochondrial damage<br>Microvascular blood flow measured by O2C<br>Mitochondrial function in peripheral blood mononuclear cells