Characteristics and Training of Neural Responding in BPD
- Conditions
- F60.31
- Registration Number
- DRKS00003287
- Lead Sponsor
- Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 120
1. Diagnosis of BPD following DSM4.
2. Remitted patients need to fullfill less than 5 DSM4criteria.
3. Healthy controls aged 18-45 without a history of psychiatric disorders.
Exclusion criteria for all participants
• Pregnancy
• Lifetime diagnosis of psychotic disorder or bipolar I disorder
• Major depressive episode at the time of measurement
• Substance dependency in the preceding year
• Organic brain diseases
• Severe medical or neurological condition
• Antecedent cranial or brain injuries
• Metallic items in or on the body
• Left-handedness
• Claustrophobia
-Chronic non-healing wounds
-blood coagulation disorder
-medication with marcumar
-anamnestic brain lesion
-psychotropic medication within the last two weeks
Additional criteria for the healthy control group:
• Fulfilling more than one DSM IV criterion for BPD
• Any psychiatric disease
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The BOLD response assessed with fMRI will be explored and better characterized. This should enhance the separation between healthy controls and BPD patients
- Secondary Outcome Measures
Name Time Method We will test the hypothesis that BPD patients are able to learn to control their emotional response by an fMRI neurofeedback training.