A clincal trial to compare the effect of two drugs, ondansetron and granisetron on propofol injection pain

• Conditions: ASA I & II patients undergoing elective surgery under general anesthesia.

• Registration Number: CTRI/2018/06/014561
• Lead Sponsor: B P Koirala Institute Of Health Sciences

Brief Summary

Propofol is the most commonly used intravenous agent for induction of anaesthesia. It causes pain at the site of injection. Different modalities have been used in the past to abolish propofol induced pain. Recently 5-HT3 receptor antagonists like ondansetron and granisetron have shown to bind to opioid Mu receptors and exhibit agonist action. Also peripheral 5-HT3 receptors are involved in noniceptive pathways. Due to their multi faceted actions on intra-vascular Na+channels, opIoid receptors and peripheral and central 5-HT3 receptors these study drugs may potentially be used to alleviate the pain caused while injecting propofol.  In our study, we attempted to find the effectiveness of ondansetron versus granisetron in reducing propofol injection pain and the hemodynamic response during laryngoscopy and tracheal intubation after pretreatment with the study drugs.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-06-17
• Last Update Posted: 2018-06-16

Recruitment & Eligibility

• Status: Not Applicable
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

ASA I & II Patients undergoing elective surgery under general anesthesia.

Exclusion Criteria

• 1.Patients allergic to the study drug.
• 2.History of chronic pain conditions and patients on analgesics or opioids on regular basis.
• 3.Emergency procedures.
• 4.Patients of ASA physical status III or more.
• 5.Known or suspected pregnancy.
• 6.Patients with peripheral vascular disease.
• 7.Expected difficult intubation.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Propofol injection pain during induction of anaesthesia.	20 seconds
To compare the effectiveness of pre-treatment of intravenous ondansetron or granisetron on:	20 seconds

Secondary Outcome Measures

Name	Time	Method
To observe the effect on post endotracheal intubation hemodynamic responses.	10 minutes

Trial Locations

Locations (1)

B P Koirala Institute Of Health Sciences; 🇮🇳 First, India

B P Koirala Institute Of Health Sciences

🇮🇳First, India

Dr vidit Kaushal

Principal investigator

8527153206

drvidit@gmail.com