Benefits of Total Intravenous Anesthesia Compared With Inhaled Anesthesia in Cardiovascular Surgery

• Conditions: Cardiovascular Surgical Procedure
• Interventions: Drug: Sevoflurane; Drug: Propofol

• Registration Number: NCT03233815
• Lead Sponsor: Coordinación de Investigación en Salud, Mexico

Brief Summary

This study compares the difference in proinflammatory markers Interleukin 6 (IL-6), Tumor necrosis factor alpha (TNFα) and cortisol in patients undergoing cardiovascular surgery to asses if there is a benefit of using intravenous total anesthesia (TIVA) over inhaled anesthesia for this procedures.

Detailed Description

IL-6, TNFα and cortisol will be measure at the beginning of the cardiovascular surgery and 20 minutes after the cardiovascular bypass ends to calculate the difference between them and compare if there is any statistical difference between the proinflammatory markers with the two anesthesia techniques.

Study Timeline

• Study First Submitted: 2017-07-26
• Study First Submitted QC: 2017-07-26
• Study First Posted: 2017-07-31
• Study Start: 2017-11-13
• Status Verified: 2020-08
• Last Update Submitted: 2020-08-05
• Last Update Posted: 2020-08-06
• Primary Completion: 2021-12
• Study Completion: 2021-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Scheduled for cardiovascular surgery American Society of Anaesthesiologists (ASA) physical status classification II-IV BMI < 25 HbA1c < 7%

Exclusion Criteria

Diabetic patients Known allergy to propofol

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Inhaled anesthesia (Sevoflurane)	Sevoflurane	Patients undergoing cardiovascular surgery with inhaled anesthesia with sevoflurane.
Total Intravenous Anesthesia (Propofol)	Propofol	Patients undergoing cardiovascular surgery with total intravenous anesthesia with propofol.

Primary Outcome Measures

Name	Time	Method
IL-6	The difference between IL-6 at the begging of surgery and 20 minutes after the end of the cardiopulmonary bypass	IL-6 will be compared between the groups.

Secondary Outcome Measures

Name	Time	Method
TNFα	The difference between TNFα at the begging of surgery and 20 minutes after the end of the cardiopulmonary bypass	TNFα will be compared between the groups
Cortisol	The difference between cortisol at the begging of surgery and 20 minutes after the end of the cardiopulmonary bypass	Cortisol will be compared between the groups

Trial Locations

Locations (1)

Hospital de cardiología; 🇲🇽 Ciudad de mexico, Cdmx, Mexico