Multimodal Imaging Studies of Neural Circuit Dynamics of the Self

Not Applicable

Recruiting

• Conditions: Psychiatric disorders (schizophrenia, mood disorders)

• Registration Number: JPRN-jRCT1032230108
• Lead Sponsor: Matsumoto Madoka

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-06-02
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 600

Inclusion Criteria

1) Normal participants without mental disorders
2) Patients with DSM-5 (Diagnostic and Statistical Manual of Mental Disorders-5) diagnosis of mental illness (schizophrenia patients, mood disorder patients) who are visiting our outpatient clinic or are hospitalized.
3) Participants with characteristics of gifted (developmental disability gray zone), with at least one of the five composite scores (full test IQ (FSIQ), verbal comprehension index (VCI), perceptual reasoning index (PRI), working memory index (WMI), processing speed index (PSI)) on any of the WAIS/WISC/WPPSI tests at least one of which exceeds 130 (Lang et al., 2019 Assessment). In addition, based on background information from the interview (gender, age, history, medical history, history of treatment, primary disease, history of allergies, history of adverse reactions, etc.), the possibility of the entry of disease groups with past and current treatment history will be eliminated.
4) Participants who are between 20 and 45 years of age.
5) Participants who have the capacity to consent in person and the ability to consent in writing

Exclusion Criteria

1) Left-handed
2) Participants with a coexisting alcohol/substance use disorder or a history of alcohol/substance use disorder within 2 years
3) Participants who are not eligible for MRI imaging due to the presence of metal in the body (e.g., brain aneurysm clips, cardiac pacemakers, etc.)
4) Patients who have difficulty entering the MRI and MEG machines due to claustrophobia.
5) Patients with evidence of cerebral organic disease
6) Patients with life-threatening serious or unstable physical diseases
7) Pregnant women
8) Participants deemed inappropriate by the principal investigator.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Elucidating the neural circuits of self disturbance in patients with schizophrenia

Secondary Outcome Measures

Name	Time	Method
Stratification of mental disorders based on neural circuits