Post-exercise recovery after dietary protein ingestion in healthy young me
Completed
- Conditions
- age-related muscle losssarcopenia1003700810028302
- Registration Number
- NL-OMON37718
- Lead Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 12
Inclusion Criteria
Males
Aged between 18-35 years
Healthy, recreationally active
BMI < 25 kg/m2
Exclusion Criteria
Smoking
Allergies to milk proteins (whey or casein)
Vegetarians
Female
Arthritic conditions
A history of neuromuscular problems
Previous participation in amino acid tracer studies
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study endpoint is the muscle protein synthesis rate, expressed as<br /><br>fractional synthetic rate (FSR). In order to determine the FSR, the following<br /><br>parameters will be measured in blood and muscle tissue:<br /><br><br /><br>Plasma and muscle free phenylalanine concentration (expressed as *mol/L)<br /><br>Plasma enrichment of L-[ ring-2H5]phenylalanine (expressed as mole percent<br /><br>excess (MPE))<br /><br>Muscle protein bound enrichment of L-[ ring-2H5]phenylalanine (expressed as MPE)<br /><br>L-[ ring-2H5]phenylalanine enrichment of the muscle free amino acid pool<br /><br>(expressed as MPE)</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary endpoints include whole body protein turnover, protein digestion and<br /><br>absorption kinetics and nitrate/nitrite analysis. The following parameters will<br /><br>be calculated:<br /><br><br /><br>Exogenous phenylalanine rate of appearance and plasma availability of<br /><br>phenylalanine.<br /><br>Total rate of phenylalanine appearance and disappearance (= protein turnover)<br /><br>Endogenous phenylalanine rate of appearance (=protein breakdown)</p><br>