Protein for muscle recovery after exercise

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

Substantial
? Male
? Age =18 and =35 years.
? BMI =18.5 and =27.5 kg/m2
? Healthy as assessed by the NIZO lifestyle and health questionnaire.
? Recreationally active, defined as performing physical activities on a recreational basis for a maximal duration of 5 hours per week.
? Veins suitable for cannulation (blood sampling)
Procedural
? Having given written informed consent.
? Willing to comply with study procedures.
? Ability to follow Dutch verbal and written instructions.
? Availability of internet connection.
? Accept use of all encoded data, including publication, and the confidential use and storage of all data for 15 years.
? Accept disclosure of the financial benefit of participation in the study to the authorities concerned.

Exclusion Criteria

Substantial
? Having a history of medical or surgical events that may significantly affect the study outcome, to be decided by the principal investigator.
? Participating in resistance exercise or exercise with a major eccentric component (e.g. (trail) running, football, volleyball, basketball, track and field) in the last 6 months.
? Regular use of the following medication: corticosteroids, antihistamines, NSAID.
? Smoking.
? Regular use of protein supplements.
? Mental status that is incompatible with the proper conduct of the study
? A self-reported reported lactose intolerance, allergy or sensitivity to dairy ingredients
? Evidence of current excessive alcohol consumption (>21 units/week) or drug (ab)use, and not willing/able to stop this during the study.
? Reported slimming or medically prescribed diet
Procedural
? Participation in any clinical trial including blood sampling and/or administration of substances up to 30 days before Day 01 of this study
? Recent blood donation (<1 month prior to Day 01 of the study)
? Personnel of HAN, NIZO and FC, their partner and their first and second degree relatives

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
isokinetic MVC defined as peak force at an angular velocity of 180°/s, as determined by dynamometry of the upper leg, before and immediately after, 3h after, and 1, 2 and 3 days after eccentric exercise

Secondary Outcome Measures

Name	Time	Method
Isokinetic MVC defined as peak force at an angular velocity of 90°/s, determined by dynamometry of the upper leg, before and immediately after, 3h after, and 1, 2 and 3 days after eccentric exercise<br>? Isometric MVC defined as peak force at a knee angle of 60° determined by dynamometry of the upper leg, before and immediately after, 3h after, and 1, 2 and 3 days after eccentric exercise<br>? Jump height assessed by vertical countermovement jump before and immediately after, 3h after, and 1, 2 and 3 days after eccentric exercise.<br>? Thigh circumference according to ISAK standards.<br>? Delayed onset muscle soreness (DOMS) assessed by VAS (100 mm) at baseline, immediately after and at 3, 24, 48, 72 and 96h post exercise.<br>Change in biomarkers of inflammation and immune function<br>