Protein for muscle recovery after exercise

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

* Male
* Age *18 and *35 years.
* BMI *18.5 and *27.5 kg/m2
* Healthy as assessed by the NIZO lifestyle and health questionnaire.
* Recreationally active, defined as performing physical activities on a recreational basis for a maximal duration of 5 hours per week.
* Veins suitable for cannulation (blood sampling)
* Having given written informed consent

Exclusion Criteria

* Having a history of medical or surgical events that may significantly affect the study outcome, to be decided by the principal investigator
* Participating in resistance exercise or exercise with a major eccentric component (e.g. (trail) running, football, volleyball, basketball, track and field) in the last 6 months.
* Regular use of the following medication: corticosteroids, antihistamines, NSAID
* Smoking
* Regular use of protein supplements
* Mental status that is incompatible with the proper conduct of the study
* A self-reported reported lactose intolerance, allergy or sensitivity to dairy ingredients
* Evidence of current excessive alcohol consumption (>21 units/week) or drug (ab)use, and not willing/able to stop this during the study.
* Reported slimming or medically prescribed diet
* Participation in any clinical trial including blood sampling and/or administration of substances up to 30 days before Day 01 of this study
* Recent blood donation (<1 month prior to Day 01 of the study)
* Personnel of HAN, NIZO or FrieslandCampina, their partner and their first and second degree relatives

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Change in muscle strength of the quadriceps muscles (isokinetic Maximal<br /><br>Voluntary Contraction (MVC)) up to 3 days after eccentric exercise, compared to<br /><br>pre-exercise strength.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>* Isometric MVC<br /><br>* Jump height assessed by vertical countermovement jump.<br /><br>* Thigh circumference.<br /><br>* Delayed onset muscle soreness (DOMS) assessed by VAS (100 mm)<br /><br>* Muscle soreness assessed by a 7 point Likert-scale for retrospective pain.<br /><br>* Muscle tenderness assessed by a manual muscle myometer.<br /><br>* Rated perceived exertion (RPE), assessed by the BORG scale.<br /><br>* Plasma creatine kinase (CK) concentrations<br /><br>* Plasma intestinal fatty acid binding protein (I-FABP) concentrations<br /><br>* Circulating neutrophils and monocytes (white blood cell count) in whole blood<br /><br>* Plasma concentrations of IL-6, MCP-1, IL-1ra, IL-8 and IL-10<br /><br>* Plasma concentrations of NGF </p><br>