comparing effects of magnesium sulphate nebulization and lignocaine nebulization in reducing postoperativ sore throat, hoarseness of voice and cough in patients undergoing general anaesthesia

Phase 3

Not yet recruiting

• Conditions: Medical and Surgical, (2) ICD-10 Condition: O||Medical and Surgical,

• Registration Number: CTRI/2025/04/085866
• Lead Sponsor: Department of anaesthesiology JLN medical college

Brief Summary

This will be prospective double blind study performed to evaluate and compare efficacy of preoperative magnesium sulphate 250mg and lignocaine 2% nebulization on the incidence and severity of postoperative sore throat, hoarseness of voice and cough in the patients undergoing surgeries under general anaesthesia with endotracheal intubation.primary objective is to assess incidence and severity of postoperative sore throat,hoarseness of voice and cough immediately after extubation followed by evert 2nd hourly till 6th hourly,12th and 24th hour.secondary objectives are haemodynamic changes like HR,SBP,DBP, MAP and SPO2.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2025-04-26
• Study Start: 2025-05-06

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• 1)patients undergoing general anaesthesia in supine position.
• 2)duration of surgery up to 3 hours 3)ASA physical status 1&2.

Exclusion Criteria

1)ASA class 3 and above 2)Mallampatti grades more than 2 3) any psychiatric disorders and history of epilepsy 4)neurological patients with raised intracranial pressure 5) patients with known CAD and IHD 6)pregnancy 7) patients sensitive or allergic to study drug.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess incidence and severity of postoperative sore throat, hoarseness of voice and cough.	To monitor effects immediately after extubation followed by every 2nd hourly till 6th hours thereafter every 12 hours and 24 hour postoperative.

Secondary Outcome Measures

Name	Time	Method
Haemodynamic changes HR,SBP,DBP,MAP & SPO2 Side effects	Hemodynamic monitoring in 1) prenebulization 2)Preinduction 3)postoperative immediately followed by 2nd hourly till 6th hour & 12th hourly & 24th hour.

Trial Locations

Locations (1)

Jawahar Lal Nehru medical college; 🇮🇳 Ajmer, RAJASTHAN, India

Jawahar Lal Nehru medical college

🇮🇳Ajmer, RAJASTHAN, India

Dr GANGUBAI BIRADAR

Principal investigator

9731753546

gangamb53@gmail.com