Comparative study of Magnesium sulphate nebulization and Lignocaine nebulization in prevention of postoperative sore throat (POST), Hoarseness of voice and Cough in patients undergoing general anaesthesia
Trial Snapshot
- Phase
- Phase 3
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- To assess incidence and severity of postoperative sore throat, hoarseness of voice and cough.
Study Overview
Brief Summary
This will be prospective double blind study performed to evaluate and compare efficacy of preoperative magnesium sulphate 250mg and lignocaine 2% nebulization on the incidence and severity of postoperative sore throat, hoarseness of voice and cough in the patients undergoing surgeries under general anaesthesia with endotracheal intubation.primary objective is to assess incidence and severity of postoperative sore throat,hoarseness of voice and cough immediately after extubation followed by evert 2nd hourly till 6th hourly,12th and 24th hour.secondary objectives are haemodynamic changes like HR,SBP,DBP, MAP and SPO2.
Study Design
- Study Type
- Interventional
- Allocation
- Computer generated randomization
- Masking
- Participant and Investigator Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •patients undergoing general anaesthesia in supine position.
- •duration of surgery up to 3 hours 3)ASA physical status 1&2.
Exclusion Criteria
- •ASA class 3 and above 2)Mallampatti grades more than 2 3) any psychiatric disorders and history of epilepsy 4)neurological patients with raised intracranial pressure 5) patients with known CAD and IHD 6)pregnancy 7) patients sensitive or allergic to study drug.
Outcomes
Primary Outcomes
To assess incidence and severity of postoperative sore throat, hoarseness of voice and cough.
Time Frame: To monitor effects immediately after extubation followed by every 2nd hourly till 6th hours thereafter every 12 hours and 24 hour postoperative.
Secondary Outcomes
- Haemodynamic changes HR,SBP,DBP,MAP & SPO2 Side effects(Hemodynamic monitoring in 1) prenebulization 2)Preinduction 3)postoperative immediately followed by 2nd hourly till 6th hour & 12th hourly & 24th hour.)