ISRCTN64639614进行中（未招募）未知
Standard versus accelerated weaning from non-invasive ventilation (NIV) in chronic obstructive pulmonary disease directed by the NIV outcomes score: a randomised controlled trial
orthumbria Healthcare NHS Foundation Trust0 个研究点目标入组 164 人开始时间: 2022年9月14日最近更新:
试验速览
- 阶段
- 未知
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 164
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Clinical diagnosis of Exacerbation of Chronic Obstructive Pulmonary Disease, complicated by acute hypercapnic respiratory failure (pH <7.35 and PaCO2 >6.5 kPa)
- •2. Age 35 years or over
- •3. Smoking history of 10 or more pack years
- •4. Low or medium risk Non-Invasive Ventilation (NIV) Outcomes score
- •5. Provision of acute NIV for 24 hours or longer
- •6. Correction of respiratory acidaemia
- •7. PaCO2 <8 kPa, or PaCO2 8-9 kPa with at least a 20% fall in PaCO2 from pre-NIV baseline value
- •8. Able to tolerate 60 minutes of unsupported breathing, confirmed by arterial blood gas (ABG)
- •9. Participants must be randomised within 24 hours of meeting the weaning criteria (based on the time of the qualifying ABG)
排除标准
- •1. Poor tolerance of NIV likely to limit adherence to protocol
- •2. Receiving home ventilation on admission, or planned referral for home ventilation on discharge
- •3. Inability to provide informed consent
- •4. Failure of another organ requiring level 2 or 3 organ support
- •5. Clinically significant pulmonary fibrosis
- •6. Metastatic cancer, advanced haematological malignancy, or other serious comorbidities, which may influence survival or decisions about ventilation within the time frame of the trial (3 months)
研究者
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