Transversus Abdominus Plane Block in Living Donor Hepatectomy

Not Applicable

Completed

• Conditions: Living Donor Hepatectomy
• Interventions: Device: surgically inserted Transversus abdominus plane catheter; Drug: Intravenous morphine; Drug: Bupevecaine; Drug: Dexmedetomedine

• Registration Number: NCT02708459
• Lead Sponsor: AlRefaey Kandeel

Brief Summary

Comparing different drugs used in Transversus abdominus plane analgesia after donor hepatectomy. Patients will be divided into three groups; control group, Bupivecaine group, and Dexmedetomedine group according to the used drug

Detailed Description

Transversus abdominus plane block for postoperative analgesia after donor hpatectomy surgery using three different drugs control group, Bupivecaine group, and Dexmedetomedine group

Study Timeline

• Study First Submitted: 2016-02-09
• Study Start: 2016-03
• Study First Submitted QC: 2016-03-14
• Study First Posted: 2016-03-15
• Status Verified: 2016-08
• Primary Completion: 2016-08
• Study Completion: 2016-08
• Last Update Submitted: 2016-08-29
• Last Update Posted: 2016-08-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• all living hepatectomy donors in Mansoura liver transplantation program

Exclusion Criteria

• refusal known sensetivity to used drugs

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Dex group	Intravenous morphine	catheter will surgically inserted in Transversus abdominus plane (TAP) plane before wound closure Postoperative analgesia will be maintained by Dexmedetomedine 0.4 mg/kg plus Bupevecaine 0.25 20 ml boluses each 8 hours for 48 hours in surgically inserted TAP catheter with rescue analgesia intravenous morphine (2mg) if VAS more 4
Dex group	surgically inserted Transversus abdominus plane catheter	catheter will surgically inserted in Transversus abdominus plane (TAP) plane before wound closure Postoperative analgesia will be maintained by Dexmedetomedine 0.4 mg/kg plus Bupevecaine 0.25 20 ml boluses each 8 hours for 48 hours in surgically inserted TAP catheter with rescue analgesia intravenous morphine (2mg) if VAS more 4
Dex group	Dexmedetomedine	catheter will surgically inserted in Transversus abdominus plane (TAP) plane before wound closure Postoperative analgesia will be maintained by Dexmedetomedine 0.4 mg/kg plus Bupevecaine 0.25 20 ml boluses each 8 hours for 48 hours in surgically inserted TAP catheter with rescue analgesia intravenous morphine (2mg) if VAS more 4
Control	Intravenous morphine	Control group where postoperative analgesia will be maintained by Morphine intravenous boluses (2 mg) if Visual analogue scale (VAS) scale more than 4.
Bupevecaine group	surgically inserted Transversus abdominus plane catheter	Postoperative analgesia will be maintained by 20 ml Bupevecaine (0.25%) boluses in surgically inserted TAP catheter each 8 hours for 48 hours with rescue analgesia intravenous morphine (2mg) if VAS more than 4
Bupevecaine group	Intravenous morphine	Postoperative analgesia will be maintained by 20 ml Bupevecaine (0.25%) boluses in surgically inserted TAP catheter each 8 hours for 48 hours with rescue analgesia intravenous morphine (2mg) if VAS more than 4
Bupevecaine group	Bupevecaine	Postoperative analgesia will be maintained by 20 ml Bupevecaine (0.25%) boluses in surgically inserted TAP catheter each 8 hours for 48 hours with rescue analgesia intravenous morphine (2mg) if VAS more than 4
Dex group	Bupevecaine	catheter will surgically inserted in Transversus abdominus plane (TAP) plane before wound closure Postoperative analgesia will be maintained by Dexmedetomedine 0.4 mg/kg plus Bupevecaine 0.25 20 ml boluses each 8 hours for 48 hours in surgically inserted TAP catheter with rescue analgesia intravenous morphine (2mg) if VAS more 4

Primary Outcome Measures

Name	Time	Method
postoperative morphine (mg) consumption in 1st 48 hours	48 hours postoperative

Trial Locations

Locations (1)

Mansoura university; 🇪🇬 Mansoura, Dkahleya, Egypt