Effect Of Topical Aerosolized Ropivacaine(0.75%)on Response To Extubation

Phase 1

Active, not recruiting

Brief Summary: Ropivacaine has long-acting local anaesthetic and topical anaesthesia wit

The ropivacaine been has reported to significantly attenuate histamine-induced.topical of ropivacaine(nebulisation, infiltration, atomization) reported to significantly reduce extubation response in a hypertensive patient.

We will hypothesize that topical application inhibiting bit hemodynamic response cough reflex during extubation in operative patient under general anaesthesia.

Recruitment & Eligibility

Inclusion Criteria

ASA PS I or II schedule, for elective surgery under general anaesthesia requiring oral endotracheal intubation with the clinically normal airway.

Exclusion Criteria

Severe cardiovascular, liver, and kidney disfunction; Allergies to amide local anesthetics; Patient with history of risk factor for perioperative aspiration of gastric ontents Difficult airway or history of maxillofacial and neck surgery; Chronic respiratory disease such as chronic obstructive pulmonary disease or asthma, recent respiratory tract infection, chronic cough, and current smoking.
Patients with reoperation because of serious adverse events such as bleeding, Anesthesia time more than 4 h, and delayed extubation (more than 1 h without extubation) Prolong surgery (more than 3 hr) Transferd to the Intensive Care Unit (ICU) with the tube were eliminated.
Medications invoving angiotensin converting enzyme inhibitor Refusal to participate in study.

Primary Outcome Measures

Name	Time	Method
1.Hemodynamic response(Mean arterial pressure & HeartRate)toextubation;	Will be assesed at extubation \| After 2 min \| After 5 min
&	Will be assesed at extubation \| After 2 min \| After 5 min
2.Cough occurring at extubation.	Will be assesed at extubation \| After 2 min \| After 5 min

Secondary Outcome Measures

Name	Time	Method

Locations (1): OTE, 1st floarGovernment Medical college and Hospital ;Nagpur
🇮🇳
Nagpur, MAHARASHTRA, India
OTE, 1st floarGovernment Medical college and Hospital ;Nagpur
🇮🇳Nagpur, MAHARASHTRA, India
Naresh
Principal investigator
9404212734
dr.naresh08@gmail.com