Clinical Observational Study into Mitochondrial Oxygenation Predicting Ominous Lactate In Trajectory around Abdominal Surgery
Recruiting
- Conditions
- iver disease
- Registration Number
- NL-OMON28542
- Lead Sponsor
- ot applicable
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
Age over 18 years
Acceptable proficiency of the Dutch language
Scheduled for major abdominal surgery, the primary focus will be on liver resection and liver transplantationsurgery
Written informed consent has been signed prior to or on admission to the surgical ward before surgery
Exclusion Criteria
Presence of mitochondrial disease
Pregnancy/lactation
Patients with skin lesions on upper arm/shoulder which impede measurements
Porphyria
Known intolerance to components of the ALA plaster
Patients uncapable of providing informed consent, due to a mental condition interfering with the ability tounderstand the provided information
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method -MitoPO2 (mmHg) measured semi-continuously peri-operatively and during 48 hours post-operatively using the automated setting of the COMET-device<br>-Lactate levels (mmol/l) measured four times per 24 hours
- Secondary Outcome Measures
Name Time Method