Clinical Observational Study into Mitochondrial Oxygenation Predicting Ominous Lactate In Trajectory around Abdominal Surgery

Completed

• Conditions: hepatectomy; large abdominal surgery; liver surgery; liver transplantation; 10019818

• Registration Number: NL-OMON49214
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Age over 18 years
Acceptable proficiency of the Dutch language
Scheduled for major abdominal surgery, the primary focus will be on liver
resection and liver transplantation surgery
Written informed consent has been signed prior to or on admission to the
surgical ward before surgery

Exclusion Criteria

Presence of mitochondrial disease
Pregnancy/lactation
Patients with skin lesions on upper arm/shoulder which impede measurements
Porphyria
Known intolerance to components of the ALA plaster
Patients uncapable of providing informed consent, due to a mental condition
interfering with the ability to understand the provided information

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- MitoPO2 (mmHg) measured semi-continuously peri-operatively and during 48<br /><br>hours post-operatively using the automated setting of the COMET-device<br /><br>- Arterial lactate levels (mmol/l) measured four times per 24 hours or until<br /><br>available</p><br>