Investigating Neural Mechanisms Underlying Olfactory Fat Perceptio

• Conditions: brain activation; odour - fat in dairy milk

• Registration Number: NL-OMON49906
• Lead Sponsor: Wageningen Universiteit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 25

Inclusion Criteria

- Aged 18 - 55 at the time of inclusion
- Normal BMI (18.5 - 25 kg/m2)
- Self-reported healthy (see *F1-1 Screening Questionnaire*)
- Willing to comply to study procedures
- Willing to be informed about incidental findings of pathology and approving
of reporting this to their general physician
- Being a consumer of dairy milk (at least once per week)
- Having a normally functioning sense of smell (scoring at least 12/16 on the
Sniffin* Sticks test)
- Being right-handed (as brain anatomy differences exist between left- and
right- handed individuals)

Exclusion Criteria

- Regular smoker (smoking one or more cigarettes per day)
- Having any dairy-related allergies or intolerances (self-reported).
- Being pregnant, lactating or planning on becoming pregnant during the study
period
- Having a psychiatric, neurological, or eating disorder
- Being employed by the Division of Human Nutrition and Health of Wageningen
University
- Participation in another medical-scientific study

MRI-related Exlcusion Criteria:
- Claustrophobic (self-reported)
- Having a contra-indication to MRI scanning (including, but not limited to):
- Pacemakers and defibrillators
- Epilepsy or family history of epilepsy
- Intraorbital or intraocular metallic fragments
- Ferromagnetic implants
- Presence of non-removable piercings on the head

- Limited sight that is not corrected with contact lenses or cannot be
corrected with our MRI safe glasses (maximum strength is +6 and -6)
- For women: lactating, being pregnant, or using an IUD as anti-conceptive
(with exception of the Mirena IUD, which is MRI safe).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Changes in brain activation (BOLD signal) due to olfactory exposure to<br /><br>different fat levels.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Fat discrimination ability (assessed using the DR A-not A discrimination<br /><br>testing methodology)<br /><br>- Quantitative ratings for odour intensity and liking, obtained using a<br /><br>continuous 100-unit visual analogue scale (VAS).</p><br>