EFFECT OF ADDING EPINEPHRINE TO COMBINATION OF BUPIVACAINE AND DEXMEDETOMIDINE IN SPINAL ANAESTHESIA FOR LOWER LIMB SURGERIES

Completed

Conditions: Medical and Surgical, (2) ICD-10 Condition: S70-S79||Injuries to the hip and thigh, (3) ICD-10 Condition: S80-S89||Injuries to the knee and lower leg, (4) ICD-10 Condition: S90-S99||Injuries to the ankle and foot,

Registration Number: CTRI/2021/01/030357

Lead Sponsor: NOT APPLICABLE

Brief Summary: This study is designed to evaluate intrathecal anesthesia and postoperative analgesia of adding epinephrine to a combination of 0.5% hyperbaric bupivacaine and dexmedetomidine.

Dexmedetomidine, a highly selective Î±2 adrenergic agonist increases the duration of anesthesia & analgesia whereas Epinephrine, a vasoconstrictor, reduces the systemic toxicity by decreased absorption of local anesthetics into the bloodstream and extends the duration of anesthesia.

We are expecting that the decrease in heart rate and blood pressure with a combination of bupivacaine and dexmedetomidine is balanced by adrenaline as it increases the same resulting in prolonged anesthesia with better hemodynamic status.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 50

Inclusion Criteria

ASA GRADE 1 AND 2 LOWER LIMB SURGERIES WITH PROBABLE DURATION OF 2 HOURS.

Exclusion Criteria

Patients refusal Contraindication to regional anesthesia Coagulopathy History of significant coexisting diseases (IHD, impaired renal functions, and severe liver disease) Chronic alcoholics and malnourished patients Atrioventricular block, incomplete or partial heart blocks, or intake of beta blockers.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Duration of analgesia	EVERY 15 MINUTES POST OPERATIVELY

Secondary Outcome Measures

Name	Time	Method
Duration of sensory block & motor block	EVERY 15 MINUTES POST OPERATIVELY

Trial Locations

Locations (1): TRAUMA CENTER IMS BHU
🇮🇳
Varanasi, UTTAR PRADESH, India
TRAUMA CENTER IMS BHU
🇮🇳Varanasi, UTTAR PRADESH, India
DR GHANSHYAM YADAV
Principal investigator
9838894169
ghanshyambhu1976@gmail.com