The Effect of Adding Epinephrine To Combination of 0.5% Hyperbaric Bupivacaine and Dexmedetomidine in Intrathecal Anaesthesia- A Prospective, Double Blinded Randomized Control Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Duration of analgesia
研究概览
简要总结
This study is designed to evaluate intrathecal anesthesia and postoperative analgesia of adding epinephrine to a combination of 0.5% hyperbaric bupivacaine and dexmedetomidine.
Dexmedetomidine, a highly selective α2 adrenergic agonist increases the duration of anesthesia & analgesia whereas Epinephrine, a vasoconstrictor, reduces the systemic toxicity by decreased absorption of local anesthetics into the bloodstream and extends the duration of anesthesia.
We are expecting that the decrease in heart rate and blood pressure with a combination of bupivacaine and dexmedetomidine is balanced by adrenaline as it increases the same resulting in prolonged anesthesia with better hemodynamic status.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 15.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA GRADE 1 AND 2 LOWER LIMB SURGERIES WITH PROBABLE DURATION OF 2 HOURS.
排除标准
- •Patients refusal Contraindication to regional anesthesia Coagulopathy History of significant coexisting diseases (IHD, impaired renal functions, and severe liver disease) Chronic alcoholics and malnourished patients Atrioventricular block, incomplete or partial heart blocks, or intake of beta blockers.
结局指标
主要结局
Duration of analgesia
时间窗: EVERY 15 MINUTES POST OPERATIVELY
次要结局
- Duration of sensory block & motor block(EVERY 15 MINUTES POST OPERATIVELY)