WOLF study: Weight loss with high intensity Functional exercise for men with Obstructive sLeep apnoea.

Not Applicable

Completed

• Conditions: Physical Medicine / Rehabilitation - Other physical medicine / rehabilitation; Obstructive Sleep Apnoea; Obesity; Respiratory - Sleep apnoea; Metabolic and Endocrine - Other metabolic disorders

• Registration Number: ACTRN12619001217190
• Lead Sponsor: The Woolcock Institute of Medical Research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-09-03
• Study Completion: 2023-06-30
• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

Men aged 18-55 years of age
BMI >27kg/m² or waist circumference >102cm if European, >90cm if non-European
Willing and medically able to participate in a supervised very low energy diet and exercise programme for a 12-week period
Obstructive Sleep Apnoea diagnosed on a PSG with AHI >15 events/hr
Willing and able to complete all assessments outlined in the participant information sheet

Exclusion Criteria

Any known contraindications to very low energy diet or exercise
o History of or current presence of eating disorders
- Unstable Cardiovascular Disease including:
o aortic aneurysm
o Severe left ventricular dysfunction/congestive heart failure
o Severe aortic stenosis
o Unstable ischemic heart disease including angina
o Endocarditis
o Pericarditis (acute)
- Irreversible respiratory disease that causes exercise limitation
- Rapidly progressive or terminal illness
- Severe psychosis or behavioural disturbance or cognitive impairment
- OSA consistently treated with continuous positive airway pressure or mandibular advancement splint
- Severe OSA that in the Physician’s opinion, requires immediate treatment.
- Insulin-Dependent Diabetes Mellitus
- Uncontrolled Type II Diabetes Mellitus

Study & Design

• Study Type: Interventional
• Study Design: Not specified