Effects of ketamine and thiopental sodium on depression, cognition and duration of seizure in patients undergoing electroconvulsive therapy
Not Applicable
- Conditions
- Major Depressive Disorder.Depressive episode
- Registration Number
- IRCT201201247202N3
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Inclusion Criteria : MDD( diagnosed on the basis of DSM IV criteria) ;HAM-D score greater than 18
Exclusion Criteria
History of any serious underlying conditions ( active CV or renal insufficiency); neurological disorders ( bulky mass or history of seizure disorders); other psychiatric diagnosis such as schizophrenia, schizoform or schizoaffective disorders, bipolar affective disorder; history of drug abuse in past six months; receiving electroconvulsive therapy in the past 6 months, verbal or auditory disorders (for ability to perform diagnostic tests)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in depression severity. Timepoint: before the first and second and after the 6th sessions of electroconvulsive therapy and 1 month after that. Method of measurement: Hamilton Rating Scale for Depression.
- Secondary Outcome Measures
Name Time Method Cognitive function. Timepoint: before the first and second electroconvulsive therapy ,after the 6th and 1 month after that. Method of measurement: Mini–mental state examination.;Seizure duration. Timepoint: in every ECT session. Method of measurement: chronometer.;Hemodynamic changes (blood presure, heart rate). Timepoint: brfore and after each electroconvulsive therapy session. Method of measurement: pulseoxymeter, sphyngomanometer.