The role of the TGF-ß/Smads signaling pathway in the osteogenic degeneration of cervical intervertebral disc in patients with cervical spondylosis undergoing surgical treatment

Phase 1

• Conditions: Osteogenic degeneration of the cervical intervertebral disc

• Registration Number: ITMCTR1900002526
• Lead Sponsor: Dongzhimen Hospital, Beijing University of Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. The patient was diagnosed as cervical spondylosis based on clinical and radiological evidence.
2. Surgery for the first time was performed after at least 6 weeks conservative treatment, which was ineffective;
3. The surgical methods were either artificial cervical disc replacement (ACDR) or anterior cervical discectomy and fusion (ACDF).

Exclusion Criteria

1. The cervical degeneration was serious, and the loss of intervertebral height was more than 80% of the adjacent normal segments.
2. Sufficient disc samples could not be obtained during operation.
3. Operative contraindications were found, such as poor cardiopulmonary function and intolerance to the surgery.
4. The patient had a history of neck injury or related surgery.
5. There was active hemorrhage or infection history of the patient.
6. There was a history of fracture, tumor, tuberculosis and other tissue-invasive diseases in the cervical spine.

Study & Design

• Study Type: Basic Science
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
p-Smad2;TGF-ß1;p-Smad3;