The Effect of Nicardipine on Kidney Function During Orthognathic Surgery Under Hypotensive Anesthesia

Not Applicable

Completed

• Conditions: Healthy Subjects
• Interventions: Drug: Nicardipine; Drug: remifentanil

• Registration Number: NCT01175746
• Lead Sponsor: Yonsei University

Brief Summary

Since nicardipine is known to protect kidney function, nicardipine infusion will result in better renal parameters measured in this study.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-08
• Study First Submitted: 2010-08-02
• Study First Submitted QC: 2010-08-04
• Study First Posted: 2010-08-05
• Primary Completion: 2011-06
• Study Completion: 2011-12
• Status Verified: 2013-06
• Last Update Submitted: 2013-06-11
• Last Update Posted: 2013-06-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 46

Inclusion Criteria

• healthy adult patients undergoing hypotensive anesthesia

Exclusion Criteria

• patients with any co-morbidity

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
nicardipine	Nicardipine	-
remifentanil	remifentanil	-

Primary Outcome Measures

Name	Time	Method
Creatinine Clearance	2hr after the start of hypotensive anesthesia	Hypotensive anesthesia means that we maintain the mean blood pressure between 55 \& 65 mmHg during surgery to decrease the blood loss.; The specific time point is exactly 2hr after we star to lower the blood pressure.