Adipokine Genetic Variations in predictingNAFLD Progression to NASH in Egyptian Patients

Completed

• Conditions: NAFLD; NASH - Nonalcoholic Steatohepatitis

• Registration Number: NCT04561895
• Lead Sponsor: Cairo University

Brief Summary

Due to the limited data concerning Egyptian population. authors aimed to investigate the differentadipokine gene polymorphism related to non alcoholic fatty liver disease incidence, prognosis and progression to steotosis and also to find different related factors including obesitu, diabetes and liver enzymes level

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-01
• Status Verified: 2020-09
• Primary Completion: 2020-09-15
• Study Completion: 2020-09-16
• Study First Submitted: 2020-09-18
• Study First Submitted QC: 2020-09-18
• Last Update Submitted: 2020-09-18
• Study First Posted: 2020-09-24
• Last Update Posted: 2020-09-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 224

Inclusion Criteria

Egyptian patients confirmed NAFLD diagnosis diabetic

Exclusion Criteria

• Pregnancy and lactation, history of alcohol abuse (as defined by an average daily consumption of alcohol > 30 g/day in men and > 20 g/day women), cirrhosis, autoimmune hepatitis and other causes of liver disease (viral hepatitis, hemochromatosis, Wilson's disease), drug induced hepatitis, chronic enteropathies, Chronic kidney disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
investigate adipokine dna polymorphism	1 months	to investigate adipokine gene polymorphism associated with prognosis of NAFLD patients
correlations	1 month	to correlate between gene polymorphism and glycated hemoglobin, liver enzyme and obesity

Trial Locations

Locations (1)

El Sahel teaching hospital; 🇪🇬 Cairo, Shobra, Egypt