Influence of Remifentanil on Postoperative Sore Throat in Patients Undergoing General Anesthesia
Not Applicable
Completed
- Conditions
- Hip Arthroplasty
- Interventions
- Procedure: Endotracheal intubation using laryngoscope
- Registration Number
- NCT03173339
- Lead Sponsor
- Keimyung University Dongsan Medical Center
- Brief Summary
This investigation is planned to compare the incidence and severity of postoperative sore throat according to the dose of remifentanil.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 92
Inclusion Criteria
- ASA I-III
- Patients scheduled for general anesthesia with endotracheal intubation
Exclusion Criteria
- Difficult airway
- Rapid sequence induction
- Recent sore throat
- Recent upper respiratory infection
- Asthma
- Chronic obstructive pulmonary disease
- Chronic cough
- Pregnancy
- Allergy to remifentanil
- Friable teeth
- History of head and neck surgery
- Multiple intubation attempts
- Regional anesthetic agents
- Gastric tube
- Dexamethasone
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Low remifentanil and high sevoflurane High sevoflurane Remifentanil was administered as 0.1 mcg/kg/min. Sevoflurane was started as 0.5 MAC. Sevoflurane dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.2 %. High remifentanil and low sevoflurane High remifentanil Sevoflurane was administered as 0.5 MAC. Remifentanil was started as 0.25 mcg/kg/min. Remifentanil dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.05 mcg/kg/min. High remifentanil and low sevoflurane Low sevoflurane Sevoflurane was administered as 0.5 MAC. Remifentanil was started as 0.25 mcg/kg/min. Remifentanil dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.05 mcg/kg/min. Low remifentanil and high sevoflurane Endotracheal intubation using laryngoscope Remifentanil was administered as 0.1 mcg/kg/min. Sevoflurane was started as 0.5 MAC. Sevoflurane dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.2 %. High remifentanil and low sevoflurane Endotracheal intubation using laryngoscope Sevoflurane was administered as 0.5 MAC. Remifentanil was started as 0.25 mcg/kg/min. Remifentanil dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.05 mcg/kg/min. Low remifentanil and high sevoflurane Low remifentanil Remifentanil was administered as 0.1 mcg/kg/min. Sevoflurane was started as 0.5 MAC. Sevoflurane dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.2 %.
- Primary Outcome Measures
Name Time Method Number of participants with sore throat At 24 hr
- Secondary Outcome Measures
Name Time Method Number of participants with hoarseness At 0, 2, 4 and 24 hr Number of participants with additional pain medication At 0, 2, 4 and 24 hr Number of participants with sore throat At 0, 2, 4 and 24 hr Number of participants with cough At 0, 2, 4 and 24 hr Visual analogue scale of postoperative pain At 0, 2, 4 and 24 hr Number of participants with nausea At 0, 2, 4 and 24 hr Number of participants with vomiting At 0, 2, 4 and 24 hr Number of participants with shivering At 0, 2, 4 and 24 hr Requirements of analgesics At 0, 2, 4 and 24 hr
Trial Locations
- Locations (1)
Keimyung University
🇰🇷Daegu, Non-US/Canada, Korea, Republic of