Influence of Remifentanil on Postoperative Sore Throat in Patients Undergoing General Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- Number of participants with sore throat
研究概览
简要总结
This investigation is planned to compare the incidence and severity of postoperative sore throat according to the dose of remifentanil.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA I-III
- •Patients scheduled for general anesthesia with endotracheal intubation
排除标准
- •Difficult airway
- •Rapid sequence induction
- •Recent sore throat
- •Recent upper respiratory infection
- •Chronic obstructive pulmonary disease
- •Chronic cough
- •Pregnancy
- •Allergy to remifentanil
- •Friable teeth
- •History of head and neck surgery
- •Multiple intubation attempts
- •Regional anesthetic agents
- •Gastric tube
- •Dexamethasone
研究组 & 干预措施
Low remifentanil and high sevoflurane
Remifentanil was administered as 0.1 mcg/kg/min. Sevoflurane was started as 0.5 MAC. Sevoflurane dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.2 %.
干预措施: Endotracheal intubation using laryngoscope (Procedure)
Low remifentanil and high sevoflurane
Remifentanil was administered as 0.1 mcg/kg/min. Sevoflurane was started as 0.5 MAC. Sevoflurane dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.2 %.
干预措施: Low remifentanil (Drug)
Low remifentanil and high sevoflurane
Remifentanil was administered as 0.1 mcg/kg/min. Sevoflurane was started as 0.5 MAC. Sevoflurane dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.2 %.
干预措施: High sevoflurane (Drug)
High remifentanil and low sevoflurane
Sevoflurane was administered as 0.5 MAC. Remifentanil was started as 0.25 mcg/kg/min. Remifentanil dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.05 mcg/kg/min.
干预措施: Endotracheal intubation using laryngoscope (Procedure)
High remifentanil and low sevoflurane
Sevoflurane was administered as 0.5 MAC. Remifentanil was started as 0.25 mcg/kg/min. Remifentanil dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.05 mcg/kg/min.
干预措施: High remifentanil (Drug)
High remifentanil and low sevoflurane
Sevoflurane was administered as 0.5 MAC. Remifentanil was started as 0.25 mcg/kg/min. Remifentanil dose was adjusted to maintain blood pressure (20% of preoperative blood pressure) and bispectral index (40-60) by 0.05 mcg/kg/min.
干预措施: Low sevoflurane (Drug)
结局指标
主要结局
Number of participants with sore throat
时间窗: At 24 hr
次要结局
- Number of participants with hoarseness(At 0, 2, 4 and 24 hr)
- Number of participants with additional pain medication(At 0, 2, 4 and 24 hr)
- Visual analogue scale of postoperative pain(At 0, 2, 4 and 24 hr)
- Number of participants with sore throat(At 0, 2, 4 and 24 hr)
- Number of participants with cough(At 0, 2, 4 and 24 hr)
- Number of participants with nausea(At 0, 2, 4 and 24 hr)
- Number of participants with vomiting(At 0, 2, 4 and 24 hr)
- Number of participants with shivering(At 0, 2, 4 and 24 hr)
- Requirements of analgesics(At 0, 2, 4 and 24 hr)