Investigation of the Atherogenic Effects of Uric Acid-modified in Endothelial Dysfunction and the the Preventional Mechanism by Anthocyanidines
- Conditions
- Cardiovascular Disease
- Interventions
- Registration Number
- NCT02797028
- Lead Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
- Brief Summary
The purpose of this study is to confirm the protective effect and mechanism of anthocyanins on hyperuricemia patients with Cardiovascular disease.
- Detailed Description
Hyperuricemia patients who have the ability to complete the intervention study in the early stage of study were selected as the research subjects. A randomized controlled double blind control method was used to study the effect of one year of anthocyanins intervention. Serum UA levels, oxidative stress, AGEs, and endothelial function are detecting in patients with hyperuricemia who were treated with anthocyanins and placebo. Providing scientific basis of anthocyanins for the treatment with hyperuricemia and delaying atherosclerosis.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 320
- Serum uric acid >420μmol/L (7mg/dL) in male, >360μmol/L (6mg/dL) in female identified as hyperuricemia patients.
- Age more than 60 years and less than 30 years old;
- acute infection, tumor, recent surgery, need for hemodialysis and autoimmune diseases.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Anthocyanidins capsule Anthocyanidins capsule Simple hyperuricemia patients and with coronary heart disease in hospital. Double blind, randomized method. The experimental group taking anthocyanins capsule. Placebo capsule Placebo capsule Simple hyperuricemia patients and with coronary heart disease in hospital. Double blind, randomized method. Control group taking placebo capsule Allopurinol Allopurinol The experimental group taking allopurinol.
- Primary Outcome Measures
Name Time Method Measurement of serum uric acid levels in all patients up to 1 months Serum uric acid (mg/dl) is determined by Uric Acid kit on an automated system.
- Secondary Outcome Measures
Name Time Method Measurement of advanced glycation end products and its receptor level in all patients up to 2 months Advanced glycation end products and its receptor level are determined by high efficiency liquid chromatography.
Trial Locations
- Locations (1)
General Hospital of Guangzhou Military Command of People's Liberation Army
🇨🇳Guangzhou, Guangdong, China