To compare the effects of Dexmeditomidine, Esmolol, and combination of both to know the stress response prevention for endotracheal intubation.

Phase 4

Active, not recruiting

• Conditions: Adult patients with ASA 1and 2 physical status scheduled for cardiac surgery

• Registration Number: CTRI/2017/11/010355
• Lead Sponsor: Vydehi Institute of Medical Sciences and Research Centre

Brief Summary

***Background and objectives:***Laryngoscopy and intubation can cause hemodynamicresponse. Various medications may be employed to control that response. In thisstudy, we aim to compare the effects of dexmedetomidine, esmolol and esmololwith dexmedetomidine on hemodynamic response.

 ***Methods:***Hundredand twenty elective surgery patients in need of endotracheal intubation, who wereAmerican Society of Anesthesiology I - II group and ages between 21 and 65years were included in a prospective, randomized, double-blind study. Systolic,diastolic, mean arterial & pulmonary pressures, heart rates, at the time ofadmittance to the operation room were recorded as basal measurements. Thepatients were randomized into four groups: Group I (*n* = 30) received 1 µg/kgdexmedetomidine, Group II (*n* = 30) received 2 mg/kg esmolol, Group III (*n*= 30) received 0.5 µg/kg dexmedetomidine plus 1 mg/kg esmolol and Group IV (*n*= 30) received 1µg/kg dexmedetomidine plus 2mg/kg esmolol with infusionover a period of 10 min before induction. The patients were intubated 2 min afterinduction. Systolic, diastolic, mean arterial & pulmonary pressures andheart rates were measured at base line, 10 minutes after drug, 2 min afterinduction before intubation and 1, 3, 5, min after intubation.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-01-07
• Last Update Posted: 2016-10-11

Recruitment & Eligibility

• Status: Closed to Recruitment of Participants
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Adult patients with ASA 1and 2 physical status scheduled for cardiac surgery.

Exclusion Criteria

Exclusion criteria included anticipated difficult intubation, emergency surgery, left ventricular ejection fraction <40%, left ventricular aneurysm, associated valvular lesions, left main coronary artery disease, severe systemic diseases involving the renal and hepatic systems, preoperative left bundle branch block, chronic obstructive pulmonary disease and intubation attempt lasting longer than 20 seconds.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
attenuation of stress response to endotracheal intubation in terms of heart rate, blood pressure and pulmonary artery pressure	Hemodynamic variables(heart rate,blood pressure and pulmonary pressure) were recorded baseline, after study drug, after induction before intubation and 1, 3, 5 minute after orotracheal intubation.

Trial Locations

Locations (1)

Department of Cardiac Anaesthesiology; 🇮🇳 Bangalore, KARNATAKA, India

Department of Cardiac Anaesthesiology

🇮🇳Bangalore, KARNATAKA, India

Dr Shio Priye

Principal investigator

9986743162

shiopriye@gmail.com