Hemodynamic Assessment of the Right Ventricle Using Pressure-volume Loop Catheter and Pulmonary Artery Catheter in Patients Undergoing Left Ventricular Assist Device Placement at the University of Minnesota Medical Center
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Right Ventricular Dysfunction
- Sponsor
- University of Minnesota
- Enrollment
- 4
- Locations
- 1
- Primary Endpoint
- End-diastolic pressure
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
This study will include the placement of a pressure volume (PV) loop catheter in the right atrium of patients undergoing left ventricular assist device (LVAD) placement and measure relevant PV loop data. Transesophageal echocardiography (TEE) and pulmonary artery (PA) catheter parameters as comparators to the PV loop will be recorded.
Detailed Description
This will be a prospective observational study design to characterize right ventricular function in 5 consecutive patients undergoing LVAD implantation at the University of Minnesota Medical Center (UMMC). Pre-, intra- and postoperative care delivery to all enrolled and consented patients will meet the standards of care otherwise delivered to patients undergoing LVAD implantation at UMMC; care delivery will be at the discretion of the clinical care team and will not be altered based on the output of the right ventricular high-fidelity conductance catheters.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing left ventricular assist device (LVAD) placement at the University of Minnesota Medical Center
Exclusion Criteria
- •Patients with a history of internal jugular vein thrombosis or known reasons for not being able to thread a central venous catheter through either internal jugular vein
- •Patients with a history of known esophageal strictures, esophageal or stomach cancer, esophageal varices, or any patient in whom a TEE is contraindicated
- •Patients with permanent pacemakers whose right ventricle is being paced and not in normal sinus rhythm
- •Patients unable to consent to participating in the study
- •Patients who are pregnant will be excluded, as part of standard care, all female patients are screened for pregnancy prior to surgery.
Outcomes
Primary Outcomes
End-diastolic pressure
Time Frame: Approximately 4-6 hours
End-diastolic pressure will be reported in units of mmHG
End-diastolic volume
Time Frame: Approximately 4-6 hours
End-diastolic volume will be reported in units of milliliters
Stroke work
Time Frame: Approximately 4-6 hours
Stroke work will be reported in units of gram meters (g\*m)
Stroke volume
Time Frame: Approximately 4-6 hours
Stroke volume will be reported in units of millilitres per square metre
End-systolic pressure
Time Frame: Approximately 4-6 hours
End-systolic pressure will be reported in units of mmHG
End-systolic volume
Time Frame: Approximately 4-6 hours
End-systolic volume will be reported in units of milliliters
Heart rate
Time Frame: Approximately 4-6 hours
Heart rate will be reported in units of beats per minute
Ejection fraction
Time Frame: Approximately 4-6 hours
Ejection fraction will be reported as a percent
Cardiac output
Time Frame: Approximately 4-6 hours
Cardiac output will be reported in units of milliliters per minute
Right ventricular dP/dt
Time Frame: Approximately 4-6 hours
Right ventricular dP/dt will be reported in units of mmHg per second