Relationship Between Homocysteine and BMD
Completed
- Conditions
- Postmenopausal Women
- Interventions
- Diagnostic Test: Dual-Energy X-ray Absorptiometry (DXA)
- Registration Number
- NCT04821492
- Lead Sponsor
- Fundación Santiago Dexeus Font
- Brief Summary
The association between Homocysteine (Hcy) levels and bone mineral density (BMD) has been debated. Some studies have found a relationship between increased Hcy plasma levels and BMD in contrast; other studies have not found a relationship. The purpose of our study was to investigate whether or not Hcy plasma levels are related to BMD in a group of postmenopausal women.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 760
Inclusion Criteria
- Postmenopausal women
- BMD measured by dual-energy X-ray absorptiometry (DXA)
Exclusion Criteria
- Primary ovarian failure
- Early menopause
- Cardiovascular, liver, or renal diseases
- Surgical menopause
- History of cancer
- Receiving treatment known to influence levels of Hcy or bone mineralization (folates or vitamin B12 supplements, menopausal hormonal treatment, corticosteroids, anticonvulsants, heparin, thiazide diuretics, and antiresorptive agents).
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Hyperhomocysteinemia Dual-Energy X-ray Absorptiometry (DXA) - Normal Hcy levels Dual-Energy X-ray Absorptiometry (DXA) -
- Primary Outcome Measures
Name Time Method Total hip T-score one year before or after Homocysteine levels Femoral neck T-score one year before or after Homocysteine levels BMD expressed in absolute values as g/cm2 one year before or after Homocysteine levels Lumbar spine T-score one year before or after Homocysteine levels
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hospital Universitario Quiron Dexeus
🇪🇸Barcelona, Spain