Comparison of Intraoperative Intravenous Lidocaine Infusion and Transversus Abdominis Plane (TAP) Block for Post-operative Analgesia Following Laproscopic Cholecystectomy
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- Pain score
Study Overview
Brief Summary
This study is aimed to determine the post operative pain after laparoscopic cholecystectomy by dividing patients into three different group. Group A will receive lidocaine 2mg/kg bolus at induction followed by 1.5mg/kg/hr infusion. Group B will receive bilateral subcostal TAP block with 0.375% 20ml Ropivicaine on each side. Group C will not receive any additional pain regime apart from the routine intraoperative analgesics. Pain score will be assessed post operatively for 24 hours at regular intervals using visual analog score.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Age group (18-65)
- •Undergoing elective Laproscopic Cholecystectomy
- •ASA status I or II
Exclusion Criteria
- •Participation in any other trial
- •Known hypersensitivity to study medications
- •Chronic Opioid used
- •Seizure disorder
Arms & Interventions
Lidocaine Group
After induction of anaesthesia, a bolus of 2mg/kg intravenous lidocaine will be given followed by Lidocaine infusion at the rate of 1.5 mg/kg/hour which will be stopped at the end of surgery.
Intervention: Lidocaine IV (Drug)
TAP group
After completion of procedure and before extubation, bilateral ultrasound guided subcoastal transversus abdominis plane (TAP) block will be performed by the primary anaesthetist. After taking aseptic measures, with patient in supine position a high frequency (6-13 MHz) linear ultrasound probe will be placed obliquely just inferior to the costal margin over the anterior abdominal wall. With the help of a 21G or 22G, 100 mm needle, 20 ml of 0.375% Ropivacaine will be injected between rectus sheath and fascia of transversus abdominis muscle, bilaterally.
Intervention: Ropivacaine (Drug)
Outcomes
Primary Outcomes
Pain score
Time Frame: At 12 hours
Pain score will be assessed using visual analog scoring system (0: No pain and 10: Worst Imaginable Pain)
Pain Score
Time Frame: At 24 hours
Pain score will be assessed using visual analog scoring system (0: No pain and 10: Worst Imaginable Pain)
Secondary Outcomes
- Post operative nausea and vomiting(On arrival, At 2 hours, 4 hours, 6 hours, 12 hours and 24 hours)
- Patient Satisfaction(At 24 hours or discharge)
Investigators
Haris Sheikh
Post-Graduate Trainee, Department of Anaesthesiology
Aga Khan University Hospital, Pakistan