Skeletal Muscle Parameters of Liver Cirrhosis in Non-invasive Imaging and Outcome
- Conditions
- Liver Cirrhosis
- Registration Number
- NCT03584204
- Lead Sponsor
- University Hospital, Bonn
- Brief Summary
The principal aim of this study is to analyse L3-SMI (skeletal muscle index) in a cohort of patients with decompensated liver cirrhosis and TIPS (transjugular intrahepatic portosystemic shunt), and compare the prognostic power with TPMT (transverse psoas muscle thickness). Furthermore, the role of myosteatosis, determined in CT by L3-SMI, MRI and ultrasound will be studied.
- Detailed Description
The principal aim of this study is to analyse L3-SMI (skeletal muscle index) in a cohort of patients with decompensated liver cirrhosis and TIPS (transjugular intrahepatic portosystemic shunt), and compare the prognostic power with TPMT (transverse psoas muscle thickness). Furthermore, the role of myosteatosis, determined in CT by L3-SMI, MRI and ultrasound will be studied.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 400
- liver cirrhosis of any etiology
- CT scan available
- HCC or any malignant disease
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Survival time up to 60 months time of survival
- Secondary Outcome Measures
Name Time Method Time to clinical acute-on-chronic liver failure up to 60 months acute-on-chronic liver failure according to EASL-CLIF-C definition (grade 1 (best) to 3 (worst)
Time to clinical acute decompensations up to 60 months time to occurrence of acute decompensations of liver cirrhosis (readmissions, hepatic encephalopathy, bleeding, ascites, hepatorenal syndrome, infections)
Development of sarcopenia up to 60 months Assessment of sarcopenia according to EASL-guideline
Trial Locations
- Locations (3)
University Hospital Bonn
🇩🇪Bonn, Germany
University of Frankfurt
🇩🇪Frankfurt, Germany
Sapienza University of Rome
🇮🇹Roma, Italy