Study of Atenolol Influence on Blood Pressure During Resistance Exercise

Phase 4

Completed

• Conditions: Blood Pressure; Exercise
• Interventions: Drug: atenolol

• Registration Number: NCT01030016
• Lead Sponsor: University of Sao Paulo

Brief Summary

The study was designed to investigate if atenolol is able to blunt blood pressure increase during resistance exercise in hypertensive subjects.

Detailed Description

The study compared intra-arterial blood pressure responses during leg-extension resistance exercise performed to fatigue at 40, 80 and 100% of 1 RM in hypertensive patients receiving placebo (first) and atenolol (second) on a single blind manner.

Study Timeline

• Study Start: 2007-05
• Status Verified: 2009-05
• Primary Completion: 2009-05
• Study Completion: 2009-05
• Study First Submitted: 2009-12-08
• Study First Submitted QC: 2009-12-09
• Study First Posted: 2009-12-10
• Last Update Submitted: 2009-12-14
• Last Update Posted: 2009-12-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• hypertension with blood pressure levels below 160/105 mmHg under placebo.
• age between 30 and 60 years
• nonobese

Exclusion Criteria

• target organ lesion
• cardiovascular risk factor
• cardiovascular disease
• physically active

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
atenolol	atenolol	subjects received 6 weeks of atenolol

Primary Outcome Measures

Name	Time	Method
blood pressure during resistance exercise	6 weeks

Trial Locations

Locations (1)

University of São Paulo; 🇧🇷 São Paulo, Brazil