Study to evaluate the role of Ketamine infusion in Total Knee Replacement surgeries
- Conditions
- Health Condition 1: null- patients planned for Total knee replacement surgeries in oncology
- Registration Number
- CTRI/2017/08/009452
- Lead Sponsor
- Tata Memorial Centre Mumbai
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
All ASA I and ASA II patients posted for total knee replacement procedure above 13 yrs of age.
Patients not willing to be the part of study.
With reconstructive surgery with major plastic flaps
On preoperative opioid/drug abuse or on chronic pain medications.
Pre-operative pathological fracture or muscle weakness of affected limb leading to limitation to mobility.
Pregnant patients
Patients in whom ketamine is to be avoided:
Raised intracranial pressure, glaucoma medications
Raised intraocular pressure
History of vertigo, auditory/visual hallucinations
On antipsychotic medications
Intra-operative common peroneal nerve damage (post-operative exclusion)
Post â??operative ventilation or hemodynamic instability preventing mobilization for more than 24 hours.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare functional recovery using TUG test at end of 72 hours <br/ ><br>Timepoint: 72 hours in the post-operative period <br/ ><br>
- Secondary Outcome Measures
Name Time Method To compare <br/ ><br>opioid requirement . <br/ ><br>pain scores <br/ ><br>maximum flexion and extension achieved captured using goniometry. <br/ ><br>satisfaction with pain management using 5 point Likert- type scale from 1 (not at all satisfied) to 5 (extremely satisfied) at 72 hours. <br/ ><br>adverse effects using vomiting score, Ramsey sedation score and dysphoric experiences <br/ ><br>functional recovery at first follow-up using oxford knee score. <br/ ><br>Timepoint: 72 hours