Remimazolam and Propofol on the Left Ventricular Strain During Anesthesia Induction for Non-cardiac Surgery
- Conditions
- Surgical Procedure, Unspecified
- Interventions
- Registration Number
- NCT05412914
- Lead Sponsor
- Konkuk University Medical Center
- Brief Summary
This study to compare the impacts of remimazolam or propofol on the left ventricular global longitudinal strain (LV-GLS) during anesthesia induction for non-cardiac surgery.
LV-GLS is analyzed by using speckle tracking technique of transthoracic echocardiography.
- Detailed Description
This study to compare the impacts of remimazolam or propofol on the left ventricular global longitudinal strain (LV-GLS) during anesthesia induction for non-cardiac surgery (n=40).
Remimazolam or propofol is randomly administered for anesthesia induction (Group-R and Group-P, respectively) The changes of LV-GLS are analyzed by using using speckle tracking technique. For this study, 2-dimensional of transthoracic echocardiography LV images (apical 2-chamber, 3-chamber, and 4-chamber views) are recorded and stored before administration of remimazolam/propofol (T0), 2 minutes after the administration (T2), 4 minutes after the administration (T4), and 6 minutes after the administration (T6).
After the completion of the study, LV-GLS values at T0, T2, T4 and T6 are determined by the off-line analyses of the recorded and stored 2D-images.
For the off-line determination of LV-GLS, an automated software of speckle-tracking technique (Qapp Autostrain-LV™, Philips) is employed.
The primary measure:
Inter-group comparison of the lowest LV-GLS value out of LV-GLS values at T2, T4, and T6.
The secondary measures:
Inter-group comparisons of the LV-GLS values at T0, T2, T4 and T8. Intra-group comparisons of the LV-GLS value at T0 vs. those at T2, T4 and T8
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 40
- left ventricular ejection fraction> 50%
- no left ventricular regional wall motion abnormality
- atrial fibrillation
- unfavorable airway
- hypotension requiring inotropic support
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Remimazolam Remimazolam infusion remimazolam infusion Propofol Propofol infusion propofol infusion
- Primary Outcome Measures
Name Time Method the averaged longitudinal strain of the left ventricle (%) 2.5 minutes inter-group comparisons of the lowest values of the longitudinal strains of the left ventricle in the transthoracic echocardiography after administering remimazolam- or propofol-administration for anesthesia induction
- Secondary Outcome Measures
Name Time Method the longitudinal strain of the left ventricle in apical 4 chamber view (%) 2.5 minutes inter-group comparisons of the longitudinal strains of the left ventricle in apical 4 chamber view of the transthoracic echocardiography after administering remimazolam- or propofol-administration for anesthesia induction
the election fraction of the left ventricle 2.5 minutes inter-group comparisons of the ejection fraction of the left ventricle in the transthoracic echocardiography after administering remimazolam- or propofol-administration for anesthesia induction
the longitudinal strain of the left ventricle in apical 2 chamber view (%) 2.5 minutes inter-group comparisons of the longitudinal strains of the left ventricle in apical 2 chamber view of the transthoracic echocardiography after administering remimazolam- or propofol-administration for anesthesia induction
the longitudinal strain of the left ventricle in apical long-axis view (%) 2.5 minutes inter-group comparisons of the longitudinal strains of the left ventricle in apical long-xis view of the transthoracic echocardiography after administering remimazolam- or propofol-administration for anesthesia induction
Trial Locations
- Locations (1)
Konkuk University Medical Center
🇰🇷Seoul, Korea, Republic of