NCT01237522已完成4 期
A Pharmacokinetic Evaluation of Metformin in Relation to the Polymorphism A270S in Healthy Caucasian Volunteers.
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Renal clearance of metformin
研究概览
简要总结
The aim of the study is to evaluate the pharmacokinetics of metformin in healthy Caucasians volunteers with and without the polymorphism A270S in OCT2,thus the study hypothesis is that renal clearance of metformin is affected in Caucasian with the known single nucleotide polymorphisms A270S in OCT2.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers
- •Written consent
- •rs316019 genotyped
- •Age 18-65 years old
排除标准
- •Daily medication
- •Alcohol abuse
- •Pregnancy
- •Breastfeeding
研究组 & 干预措施
Homozygote for the A270S wildetype
Active Comparator
干预措施: Metformin (Drug)
Homo- or heterozygote for A270S minor alleles
Active Comparator
干预措施: Metformin (Drug)
结局指标
主要结局
Renal clearance of metformin
时间窗: 24 Hours
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
已完成
1 期
A Study of Effect of LY3556050 on Metformin in Healthy ParticipantsHealthyNCT05615467Eli Lilly and Company18
已完成
1 期
BG00012 Regional Absorption StudyHealthyNCT01924832Biogen32
已完成
不适用
Study to Learn More About Outcomes Reported by Patients Suffering From Type 2 Diabetes Using a Digital Data Collection ToolDiabetes Mellitus, Type 2NCT04383041Bayer32
进行中（未招募）
早期 1 期
Methemoglobin Concentration in High Dose Inhaled Nitric OxideHealthy SubjectsNCT05612074Massachusetts General Hospital10
已完成
1 期
A Research Study of How NNC0174-0833 Behaves in Japanese and Caucasian Volunteers Who Are Normal Weight, Overweight or With ObesityOverweightObesityNCT03787225Novo Nordisk A/S66