Effects of Vitamin D Supplementation on Muscle Function Among Grave's Disease Patients

Not Applicable

Completed

• Conditions: Graves Disease
• Interventions: Dietary Supplement: Vitamin D supplements; Dietary Supplement: Placebo

• Registration Number: NCT06451016
• Lead Sponsor: Frontier Medical and Dental College, Abbotabad

Brief Summary

Introduction:

A deficit in vitamin D may be involved in the development and presentation of Graves' disease (GD). Lack of vitamin D and GD are linked to deteriorating quality of life (QoL) and weakening of the muscles. Our goal was to look at the possible advantages of vitamin D supplementation for the improvement of thyroid-related QoL and muscle function in GD patients, as well as the possible drawbacks of anti-thyroid drugs (ATD).

Methodology:

A multicenter randomized controlled experiment with single-blinding was carried out with 48 patients who had been diagnosed with Graves' illness. The participants were split into two groups n=24 patients in each group. In addition to standard ATD, Group A received either 70 μg (2800 IU) of vitamin D daily or a corresponding placebo. Investigator measured muscular function and isometric strength at baseline, three, and nine months.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-01
• Primary Completion: 2023-12-30
• Study Completion: 2024-01-15
• Study First Submitted: 2024-05-29
• Status Verified: 2024-06
• Study First Submitted QC: 2024-06-05
• Study First Posted: 2024-06-10
• Last Update Submitted: 2024-06-13
• Last Update Posted: 2024-06-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

• Grave's Disease
• either starting or about to start anti-thyroid medication (ATD)

Exclusion Criteria

• Chronic granulomatous disease
• hypercalcemia
• poor renal function (eGFR < 45 ml/min)
• the presence of malignant disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Vitamin D group	Vitamin D supplements	-
Control Group	Placebo	-

Primary Outcome Measures

Name	Time	Method
Muscle Strength	base line and after 3months	Hand Grip strength was measured using dynamometer

Trial Locations

Locations (2)

Frontier Medical and Dental College; 🇵🇰 Abbottābād, KPK, Pakistan

Frontier Dental; 🇵🇰 Abbottābād, Sindh, Pakistan