Comparison of effect of two different blood products for the treatment of receeding gums- A controlled randomized clinical study

Phase 4

Not yet recruiting

• Conditions: Gingival recession,

• Registration Number: CTRI/2023/06/053877
• Lead Sponsor: Dr. Richa Saroj

Brief Summary

Gingival recession is the apicalmigration of gingival margin to the cemento-enamel junction (CEJ). The distancebetween the CEJ and gingival margin gives the level of recession. Gingivalrecession can be caused by periodontal disease, accumulations, inflammation,improper flossing, aggressive tooth brushing, incorrect occlusal relationships,and dominant roots. These can appear as localized or generalized gingivalrecession. Although connective tissuegraft is a gold standard procedure, PRF can be used as an alternative procedureby keeping patient’s comfort in mind**.**PRF is a three-dimensional fibrin network that promotesaccelerated wound healing, immunity and effective neovascularization, and itsupports the three crucial steps of wound healing: ‘angiogenesis’, ‘immunity’and ‘epithelial proliferation’. In addition, PRF, an autogenous fibrin matrixformed only of concentrated blood, provides successful clinical outcomes forthe treatment of soft-tissue defects and comparable keratinized tissue gain andtissue thickness when combined with connective tissue grafts. A newerplatelet concentrate i.e. Titanium Activated PRF (T-PRF) is a 3rd generationplatelet concentrate that helps in regeneration of tissue. Titanium-Prepared,Platelet-Rich Fibrin (T-PRF) was recently developed by Tunali, et al. thatavoids any negative effects caused by dry glass or glass-coated plastictubes. The method is built on the concept that Titanium tubes aremuch more effective than glass tubes at stimulating clotting factors thanChouckroun’s method. T-PRF plays an importantrole in increasing soft tissue thickness.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-07
• Last Update Posted: 2023-10-06

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• 1.Participants between 18 and 50 years of age 2.Cairo Class I or II gingival recession defects measuring ≥ 2mm.
• 3.Vital teeth, free of faulty restorations.
• 4.Patients who gave informed consent for the study.

Exclusion Criteria

• 1.History of smoking or tobacco consumption 2.Pregnant or lactating women 3.Patient with active periodontal infection.
• 4.Patients with systemic condition that contraindicate surgery.
• 5.Patients with removable or fixed dentures in the area of interest.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Width of keratinized Tissue	Baseline - on the day of surgery & at 3 months
2. Recession Height	Baseline - on the day of surgery & at 3 months
3. Recession Width	Baseline - on the day of surgery & at 3 months

Secondary Outcome Measures

Name	Time	Method
1. Percentage Root Coverage	2. Thickness of Attached Gingiva

Trial Locations

Locations (1)

K.M Shah Dental College and Hospital; 🇮🇳 Vadodara, GUJARAT, India

K.M Shah Dental College and Hospital

🇮🇳Vadodara, GUJARAT, India

Dr Richa Saroj

Principal investigator

7208892027

richasaroj43@gmail.com