Comparison of Ondansetron and Lidocaine on reducing injection pain of Propofol: a controlled randomized study
Phase 1
- Conditions
- Severe pain at intravenous injection site during induction with Propofol in the patients who undergoing general anesthesiaOndansetron,Lidocaine,Injection pain of Propofol
- Registration Number
- TCTR20190720001
- Lead Sponsor
- Faculty of Medicine, Prince of Songkla university
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 240
Inclusion Criteria
- the American Society Anesthesiologists physical status Iâ€III
- aged between 18-65 year-old
- underwent elective surgeries under general anesthesia
- having an IV catheter no. 20 at a hand dorsum
- weight more than 50 kg
Exclusion Criteria
- had difficulty in communicating
- were allergic to ondansetron or propofol or lidocaine
- were allergic to egg or soybean
- were using Apomorphine, Dronedarone, Monoamine oxidase inhibitor and serotonergic drugs
- Arrhythmia: Prolong QT, second and third degree AV block
- Chronic pain
- Thrombophlebitis or peripheral neuropathy
- Pregnancy or during lactation
- rapid sequence intubation
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain incidence [ Verbal numerical rating scale at least 1] after injected propofol for 30 seconds asking from the patient
- Secondary Outcome Measures
Name Time Method ausea and vomitting incidence evaluate at post anesthetic care unit observe and record