Characterization of the Physiological and Subjective Satiety Response to Preloads Varying in Bioactive Dairy Proteins
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Post-prandial satiety
研究概览
简要总结
Assessing 5 different milk derived proteins versus placebo for appetite regulation and satiety, delivered via shake vehicle.
详细描述
Assessing 5 different milk derived proteins versus placebo for appetite regulation and satiety, delivered via shake vehicle. Subjects will attend a 5 hour post-prandial study day. Subjects will keep food records 1 and 3 days prior to study visit, day of visit, and day after visit; food to be weighed using study provided dietary scale.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Unrestrained (score ≤ 10 on the Eating Inventory (EI) questionnaire, Stunkard and Messick 1985)
- •18 years of age
- •Consume a low/moderate protein diet (12-20% protein energy).
- •Meet BMI criteria of 19 to 24 kg/m2 OR 29 to 34 kg/m2, inclusive.
排除标准
- •Women who score ≥ 10 on the Beck Depression Inventory (BDI, Beck and Beamesdorfer 1974)
- •Women who score ≥ 30 on Eating Attitudes Test (EAT, Garner and Garfinkel 1979),
- •Have current or past (previous 1 year) medical conditions that may interfere with any of the outcomes of this study.
- •Weigh less than 110 lbs
- •Are currently or have been modifying diet or exercise patterns to gain or lose weight in previous 60 days
- •Have unstable body weight (fluctuations of ≥ 5 kg in 60 day period)
- •Are excessive exercisers or trained athletes
- •Taking any medications that would affect appetite or any other study-described endpoint will also be excluded.
- •Allergies or intolerances to foods consumed in the study.
- •Pregnant/lactation
研究组 & 干预措施
Whey-CMP
Complete whey protein missing the CMP (aka GMP) portion of the peptide.
干预措施: Whey-CMP (Other)
Control
Placebo preload control, matched for energy.
干预措施: Control (Other)
MPI
Complete milk protein.
干预措施: MPI (Other)
CPI (casein)
Preload containing casein.
干预措施: CPI (Other)
CMP (casinomacropeptide)
Small peptide cleaved from complete whey protein.
干预措施: CMP (Other)
Whey protein
Complete whey protein.
干预措施: Whey (Other)
结局指标
主要结局
Post-prandial satiety
时间窗: 6 hours
Blood biochemical markers of appetite regulation.
次要结局
- Extended satiety(48 hours)