Anti-inflammatory effect of ketamine versus dexmedetomidine in laparoscopic hysterectomy

Phase 3

Recruiting

• Conditions: Urological and Genital Diseases; Anaesthesia

• Registration Number: PACTR201910617459894
• Lead Sponsor: amees Mohamed Dawood

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-10-24
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 75

Inclusion Criteria

seventy five female patients,
aged 30-60,
ASA physical status I –II,
scheduled for elective laparoscopic hysterectomy

Exclusion Criteria

patient refusal,
severe respiratory or cardiac disorders,
hepatic or renal insufficiency,
allergy to any of the study drugs,
severe obesity (body mass index >35 kg m-2),
uncontrolled diabetes,
use of any drug that might affect the immunity as chemotherapy or hormonal treatment.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
assessment of the inflammatory mediators; tumor necrosis factor-alpha (TNF-a), interleukin 6 (IL-6), and C-reactive protein (CRP)

Secondary Outcome Measures

Name	Time	Method
Mean arterial blood pressure and heart rate ;Recovery time ;Adverse effects: postoperative nausea and vomiting, over-sedation,bradycardia, hypotension, psychomimetic change as agitation, hallucinations, or vivid dreams