Comparison of Propofol and Sevoflurane as a Primary Anesthetic for Cardiac Ablation of Atrial Fibrillation.

Not Applicable

Completed

• Conditions: Atrial Fibrillation
• Interventions: Drug: sevoflurane; Drug: propofol

• Registration Number: NCT02697448
• Lead Sponsor: Medical University of South Carolina

Brief Summary

Comparison of propofol and sevoflurane as a primary anesthetic for cardiac ablation of atrial fibrillation

Detailed Description

A side effect of some volatile anesthetics, such as isoflurane and desflurane, is enhanced automaticity, accounting for secondary atrial pacemakers. Volatile anesthetics also have varying effects on the AV node and His-Pukinje system. These agents also prolong the QT interval and, for this reason, volatile anesthetics as a group have at times been avoided for atrial fibrillation ablation due to the fear that they may affect the efficacy of the ablation and increase recurrence. However, sevoflurane does not have the effects shown for other volatile anesthetics cardiac conduction. At this point there has not been a study comparing propofol, a non volatile anesthetic typically used in these cases, to sevoflurane, a volatile anesthetic, to determine if volatile anesthetics should be avoided during these procedures. This study will challenge the existing belief that sevoflurane increases the length of time to ablate atrial fibrillation and also decreases the efficacy of the ablation.

Study Timeline

• Study First Submitted: 2016-02-29
• Study First Submitted QC: 2016-02-29
• Study First Posted: 2016-03-03
• Study Start: 2016-06-08
• Primary Completion: 2023-06-30
• Study Completion: 2024-02-28
• Results First Submitted: 2024-05-16
• Status Verified: 2024-07
• Results First Submitted QC: 2024-07-26
• Last Update Submitted: 2024-07-26
• Results First Posted: 2024-08-20
• Last Update Posted: 2024-08-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 135

Inclusion Criteria

• have paroxysmal atrial fibrillation
• undergoing their first ablation.

Exclusion Criteria

• none

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
sevoflurane	sevoflurane	Participants receiving sevoflurane as anesthetic for cardiac ablation.
propofol	propofol	Participants receiving propofol as anesthetic for cardiac ablation.

Primary Outcome Measures

Name	Time	Method
Procedure Duration	1 day	The duration of the procedure in minutes.
Time to Extubation	Procedure end time to time of extubation	The time from procedure end to the time the patient is extubated, in minutes. A longer extubation time is a worse outcome.

Trial Locations

Locations (1)

Medical University of South Carolina; 🇺🇸 Charleston, South Carolina, United States