The characterization of T cells that reside in kidney transplants
Completed
- Conditions
- 10029149n.a.
- Registration Number
- NL-OMON39128
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
A patient must be over 18 years of age.
A patient must have undergone a kidney transplantation and must be treated by nephrologists from the Renal Transplant Unit in the Academic Medical Centre.
A patient must be eligible for a kidney biopsy in the context of standard clinical indications.
Exclusion Criteria
All patients who do not meet any of the inclusion criteria
All patients who experience any serious adverse events will be excluded from further participation in this study
All patients for whom it is regarded unsafe for any reason, by the treating transplant nephrologist, to undergo the interventions described in detail in the study protocol.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>T cell phenotypes<br /><br>Specificity of circulating and renal-residing T cells<br /><br>Function of kidney-resident T cells<br /><br>Cross-reactivity of kidney-resident T cells </p><br>
- Secondary Outcome Measures
Name Time Method <p>Renal biopsies contain renal tubular epithelial cells, which seem to play a<br /><br>role in shaping the immuneresponse against viruses. We will isolate renal<br /><br>tubular epithelial cells, after T cell isolation and use these cells to<br /><br>elucidate the role of renal epithelial cells in immunresponses against virusses<br /><br>and in allograft rejection. </p><br>