Endocrine profile of PerIcoronary adipose tissue in relation to Coronary ARtery Disease study

Completed

Conditions: Atherosclerosis
coronary artery disease
10011082
10018424
10003216

Registration Number: NL-OMON36488

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 46

Inclusion Criteria

Inclusion criteria
1. Written and signed informed consent.
2. Male or female patients.
3. Scheduled for elective CABG.
4. >= 50% stenosis of the RCA, LAD, diagonal branche of the LAD (DIAG) or mo branches of the RCx.

Exclusion Criteria

Exclusion criteria
1. Thyroid disease (TSH < 0.35 or > 5.0 mU/L or use of thyroid hormones)
2. History of malignancy (in the last 2 years)
3. Use of thiazolidinediones
4. Use of immune suppressive medication (equivalent of prednisolon >= 10 mg /day)
5. Renal failure GFR< 30 (ml/min/1.73m2)
6. History of cardiothoracic surgery
7. History of percutaneous coronary intervention
8. coronary artery disease of more than 2 vessels

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>onderzoeksvariabelen:<br /><br>- Adipokine en cytokine mRNA expression (RT-PCR) and secretion (Western<br /><br>blotting):<br /><br>adiponectin, IL-6, TNF-a, resistin, PAI-1 en visfatin<br /><br>- Histologic parameters of inflammation: macrophage infiltration (macrophages<br /><br>per view), capillary injection (capillaries per view) en fat necrosis (presence<br /><br>of) .<br /><br><br /><br>outcome measures:<br /><br>- Stenosis (atherosclerotic plaque) measured with coronary angiography. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Plasma adipokine and cytokine concentrations (adiponectine, IL-6, TNF-a,<br /><br>resistin, PAI-1 en visfatin)<br /><br>- Parameters of the metabolic syndrome (waist circumference (cm), LDL-c, HDL-c,<br /><br>total cholesterol, fasting glucose, blood pressure)<br /><br>- Adipocyte size</p><br>