Analgesic Efficacy of Blocking Nerve to Vastus Lateralis Muscle Versus Lateral Femoral Cutaneous Nerve After Knee Surgeries

Not Applicable

Recruiting

• Conditions: Analgesia; Vastus Lateralis Nerve Block; Lateral Femoral Cutaneous Nerve Block; Knee Surgeries
• Interventions: Drug: Vastus lateralis nerve block; Drug: Lateral femoral cutaneous nerve block

• Registration Number: NCT06809842
• Lead Sponsor: Kafrelsheikh University

Brief Summary

This study aims to compare the analgesic efficacy and functional outcomes of blocking the nerve to the vastus lateralis (NVL) muscle versus the lateral femoral cutaneous nerve (LFCN).

Detailed Description

Knee surgeries are associated with significant postoperative pain, which can impede early mobilization and prolong recovery. Recent advancements in ultrasound-guided regional anesthesia have enabled more targeted nerve blocks, such as the blockade of the nerve to the vastus lateralis (NVL) and the lateral femoral cutaneous nerve (LFCN)

Study Timeline

• Study First Submitted: 2025-01-30
• Study First Submitted QC: 2025-01-30
• Status Verified: 2025-02
• Study Start: 2025-02-05
• Study First Posted: 2025-02-05
• Last Update Submitted: 2025-02-05
• Last Update Posted: 2025-02-06
• Primary Completion: 2025-07-30
• Study Completion: 2025-07-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Age ≥ 18 years.
• Both sexes.
• American Society of Anesthesiologists (ASA) physical status from I to III.
• Underwent knee surgeries under spinal anesthesia.

Exclusion Criteria

• Pregnancy.
• Coagulopathy.
• Neuromuscular disorders.
• Hematological disorders.
• Mental disorders.
• History of multiple traumas or anesthesia drug allergies.
• Local skin infection at the block site.
• Body mass index (BMI) greater than 40.
• Opioid analgesics or abusing opioids.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Vastus lateralis nerve block group	Vastus lateralis nerve block	Patients will receive vastus lateralis nerve block.
Lateral femoral cutaneous nerve block group	Lateral femoral cutaneous nerve block	Patients will receive lateral femoral cutaneous nerve.

Primary Outcome Measures

Name	Time	Method
Degree of pain	24 hours postoperatively	Each patient will be instructed about postoperative pain assessment using the numeric rating scale (NRS) score (0 represents "no pain" while 10 represents "the worst pain imaginable"). NRS assessments will be conducted at the post-anesthesia care unit (PACU) and at 2, 4, 6, 12, 18, and 24 hours postoperatively.

Secondary Outcome Measures

Name	Time	Method
Incidence of adverse events	24 hours postoperatively	Incidence of adverse events such as postoperative nausea and vomiting (PONV), respiratory depression, and local anesthetic (LA) toxicity will be recorded.
Time to first request for analgesia	24 hours postoperatively	The time to first request for analgesia will be recorded from the end of surgery till the first dose of morphine is administered.
Block performance time	Intraoperatively	The block performance time will be recorded from the placement of the ultrasound probe to the removal of the needle after the injection of local anaesthetic.
Degree of patient satisfaction	24 hours postoperatively	The degree of patient satisfaction will be measured using a 5-point Likert scale (1 = extremely dissatisfied, 2 = unsatisfied, 3 = neutral, 4 = satisfied, 5 = extremely satisfied).
Total morphine consumption	24 hours postoperatively	If the numeric rating scale (NRS) exceeded 3, rescue analgesia in the form of a 3 mg morphine bolus will be administered, to be repeated after 30 minutes if the pain persisted until the NRS dropped below 4.
Length of hospital stay	Till the discharge from hospital (Up to one week).	Length of hospital stay will be recorded from admission till discharge from the hospital.

Trial Locations

Locations (1)

Kafrelsheikh University; 🇪🇬 Kafr Ash Shaykh, Kafrelsheikh, Egypt