The Role of Dietary Intake and Host Genetics in Gut Microbiome Response to Resistant Starch Consumption
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 196
- 试验地点
- 2
- 主要终点
- Gut microbiome
研究概览
简要总结
Resistant starch (RS), a type of dietary fiber, was shown to have beneficial effects on human health through its impact on microbes present in the intestine. However, the effects of RS on the gut microbiota and in turn, on human health, can vary between individuals. Consequently, everyone may not reap the same health benefits by eating high amounts of RS. Factors predicting how an individual's gut microbes as well as the beneficial metabolites produced by these microbes respond to RS supplementation would be helpful in developing precision nutrition approaches that maximize the benefits of dietary fiber intake. The objective of this study was to evaluate candidate predictors of gut microbiota response to RS supplementation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Above 18 years of age
- •Willing to consume the supplements provided throughout the duration of the study
排除标准
- •History of diabetes, prediabetes or impaired glucose tolerance.
- •Existing, UNTREATED, thyroid condition.
- •Usage of systemic antibiotics (intravenous injection, intramuscular, or oral) within 6 months prior to the study.
- •Acute disease at the time of enrollment.
- •Chronic, clinically significant pulmonary, cardiovascular, gastrointestinal, hepatic, or renal functional abnormality.
- •History of active UNTREATED gastrointestinal disorders or diseases including:
- •i. Inflammatory bowel disease (IBD) ii. Ulcerative colitis (mild-moderate-severe) iii. Crohn's disease (mild- moderate-severe) iv. Indeterminate colitis v. Irritable bowel syndrome (IBS) (moderate-severe) vi. Persistent, infectious gastroenteritis, colitis or gastritis vii. Persistent or chronic diarrhea of unknown etiology viii. Clostridium difficile infection (recurrent) ix. Chronic constipation
- •Suspected state of immunosuppression or immunodeficiency including HIV.
- •History of bariatric surgery.
- •Pregnant or lactating women.
结局指标
主要结局
Gut microbiome
时间窗: 7 weeks
16S rRNA gene survey of gut microbial communities
Fecal short-chain fatty acid concentration
时间窗: 7 weeks
Fecal short-chain fatty acid concentration measurements with ultra-performance liquid chromatography
次要结局
未报告次要终点